Effect of a single point mutation on equine herpes virus 9 (EHV-9) neuropathogenicity after intranasal inoculation in a hamster model
Journal of Veterinary Medical Science, ISSN: 1347-7439, Vol: 79, Issue: 8, Page: 1426-1436
2017
- 5Citations
- 6Captures
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Metrics Details
- Citations5
- Citation Indexes5
- CrossRef5
- Captures6
- Readers6
Article Description
This study aimed to investigate the neuropathogenesis of equine herpes virus 9 (EHV-9) by studying the effects of a single point mutation introduced in two different EHV-9 genes. The two EHV-9 mutants, 14R and 19R, were generated carrying a point mutation in two separate EHV-9 genes. These mutants, along with the wild-type EHV-9, were used to infect a hamster model. The EHV-9- and 19R-infected groups showed earlier and more severe clinical signs of infection than the 14R-infected group. The white blood cells (WBCs) count was significantly increased in both EHV-9- and 19R-infected groups compared to the 14R-infected group at the 4th day post infection (DPI). Viremia was also detected earlier in both EHV-9- and 19R-infected groups than 14R-infected group. There were differences in the anterograde transmission pattern of both EHV-9 and 19R compared to 14R inside the brain. Serum TNF-α, IL-6 and IFN-γ levels were significantly increased in both EHV-9- and 19R-infected groups compared to the 14R-infected group. Histopathological and immunohistochemical analyses revealed that the mean group scores for the entire brain were significantly higher in both EHV-9- and 19R- infected groups than 14R-infected group. Collectively, these results confirm that the gene product of Open Reading Frame 19 (ORF19) plays an important role in EHV-9 neuropathogenicity and that the mutation in ORF19 is responsible for the attenuation of EHV-9.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85027703687&origin=inward; http://dx.doi.org/10.1292/jvms.17-0076; http://www.ncbi.nlm.nih.gov/pubmed/28717112; https://www.jstage.jst.go.jp/article/jvms/79/8/79_17-0076/_article; https://dx.doi.org/10.1292/jvms.17-0076; https://www.jstage.jst.go.jp/article/jvms/79/8/79_17-0076/_article/-char/en/; https://www.jstage.jst.go.jp/article/jvms/79/8/79_17-0076/_article/-char/ja/
Japanese Society of Veterinary Science
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