Ethanol extract of Annona muricata. L induces liver cancer cell apoptosis through ROS pathway
Biomedical and Pharmacology Journal, ISSN: 0974-6242, Vol: 9, Issue: 3, Page: 919-925
2016
- 13Citations
- 43Captures
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Article Description
The study investigated the underlying molecular mechanisms of ethanol extract of Annona muricata. L induced liver cancer cell apoptosis. The anti-proliferative effect of ethanol extract of Annona muricata. L was evaluated by MTT assay. Flow cytometry was used to detect the cell cycle and apoptosis. TUNEL assay was used to confirm cell apoptosis. DCFH-DA fluorescent probe can detect the level of intracellular reactive oxygen species (ROS). Different concentrations of ethanol extract of Annona muricata. L leaves (0, 30, 60, 120, 240 μg/ml) were used to treat liver cancer HepG2 cells for 24h or 48h, the cell viability was inhibited in time- and dose-dependent manners. Ethanol extract of Annona muricata. L leaves increased the number of cells in the sub- G1 fraction in a dose-dependent manner. TUNEL assay confirmed that the extract caused apoptosis of the cancer cells. Further analysis revealed that the extract produced reactive oxygen species (ROS). Antioxidant N-acetylcysteine was able to inhibit the extract-triggered ROS production and apoptosis. In conclusion, our results suggest that the ethanol extract of Annona muricata. L leaves induces HepG2 cell apoptosis through ROS pathway.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85019865987&origin=inward; http://dx.doi.org/10.13005/bpj/1030; http://biomedpharmajournal.org/vol9no3/ethanol-extract-of-annona-muricata-l-induces-liver-cancer-cell-apoptosis-through-ros-pathway/; https://dx.doi.org/10.13005/bpj/1030; https://biomedpharmajournal.org/vol9no3/ethanol-extract-of-annona-muricata-l-induces-liver-cancer-cell-apoptosis-through-ros-pathway/
Oriental Scientific Publishing Company
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