A validated RP-HPLC method for simultaneous determination of eberconazole, mometasone furoate and methylparaben
Oriental Journal of Chemistry, ISSN: 0970-020X, Vol: 29, Issue: 2, Page: 579-587
2013
- 3Citations
- 6Captures
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Article Description
A novel, sensitive and selective isocratic reverse phase high performance liquid chromatographic method was developed and validated for quantitative determination of eberconazole, mometasone furoate and methylparaben in ointment formulations. The chromatographic separation was achieved on Waters Symmetry C-18 (250 × 4.6mm, 5μ) column by using mobile phase containing a mixture of solvent A (0.5g of 1-Hexane sulphonic acid sodium salt and 0.5mL of triethyl amine in 500mL of Milli-Q water, pH 6.0) and B (acetonitrile) in the ratio of 20:80 at flow rate of 1.0 mL/min. Column temperature was maintained at 30°C and detection was carried out at a wavelength of 240 nm. The developed method was validated with respect to specificity, linearity, precision, accuracy and robustness. Forced degradation studies were performed on the placebo and drug product, all degradation products were well separated from eberconazole, mometasone furoate and methylparaben.
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