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Comparative analysis of various aspects of plateletpheresis on the Fenwal Amicus and Fresenius COM.TEC cell separator instruments

Laboratory Medicine, ISSN: 1943-7730, Vol: 45, Issue: 4, Page: 315-323
2014
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Metric Options:   Counts1 Year3 Year

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Article Description

Objective: To compare the Fenwal Amicus and the Fresenius COM.TEC apheresis instruments regarding donor peripheral blood parameters, operational variables of the instruments, and quality control parameters of the product obtained. Methods: We performed 100 platelet collections from 100 voluntary donors using the 2 studied devices. We measured platelet count using an automated analyzer and analyzed the activation statuses using a flow cytometer. Results: The median time needed to perform the procedures was significantly longer with the COM.TEC. However, the product we obtained using the Amicus instrument showed higher degrees of platelet-activation. All products we obtained with both instruments had white blood cell counts of less than 5 × 106 per bag. We observed no statistical difference regarding collection efficiency and collection rates between the devices. Conclusion: Both instruments collected platelets efficiently, with minimal donor discomfort. Compared with the COM.TEC instrument, the Amicus reached the platelet target yield more quickly; however, it displayed an increase in platelet activation.

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