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The effect of APOC3 promoter polymorphisms on the risk of hypertriglyceridemia in Chinese Han population with or without type 2 diabetes mellitus

Laboratory Medicine, ISSN: 0007-5027, Vol: 41, Issue: 1, Page: 34-39
2010
  • 6
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  • 12
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Metrics Details

  • Citations
    6
    • Citation Indexes
      6
  • Captures
    12

Article Description

Background: Promoter polymorphisms in the apolipoprotein C3 (APOC3) gene are associated with hypertriglyceridemia (HTG), which is a complication of Type 2 Diabetes Mellitus (T2DM). Because there is a strong insulin resistance in T2DM, it is essential to investigate whether the APOC3 promoter variation affects plasma lipid profiles in the population with or without T2DM. Methods: Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed to detect the genotypes of APOC3. The levels of serum lipid profiles were also studied by biochemical methods. Results: In the control group, the prevalence of the -455CC or -482TT variants was higher in persons with HTG compared to those with normal triglyceride (NTG). Compared with the most common genotype, -455TT or -482CC, the variants had a significantly increased HTG risk in this population. However, a similar association was not found in the T2DM group. Conclusions: There was no relationship between promoter rare allele -455C or -482T of APOC3 gene and HTG in T2DM, but both the rare alleles contributed to an increased risk of HTG in the control group without T2DM.

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