The effect of APOC3 promoter polymorphisms on the risk of hypertriglyceridemia in Chinese Han population with or without type 2 diabetes mellitus
Laboratory Medicine, ISSN: 0007-5027, Vol: 41, Issue: 1, Page: 34-39
2010
- 6Citations
- 12Captures
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Article Description
Background: Promoter polymorphisms in the apolipoprotein C3 (APOC3) gene are associated with hypertriglyceridemia (HTG), which is a complication of Type 2 Diabetes Mellitus (T2DM). Because there is a strong insulin resistance in T2DM, it is essential to investigate whether the APOC3 promoter variation affects plasma lipid profiles in the population with or without T2DM. Methods: Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed to detect the genotypes of APOC3. The levels of serum lipid profiles were also studied by biochemical methods. Results: In the control group, the prevalence of the -455CC or -482TT variants was higher in persons with HTG compared to those with normal triglyceride (NTG). Compared with the most common genotype, -455TT or -482CC, the variants had a significantly increased HTG risk in this population. However, a similar association was not found in the T2DM group. Conclusions: There was no relationship between promoter rare allele -455C or -482T of APOC3 gene and HTG in T2DM, but both the rare alleles contributed to an increased risk of HTG in the control group without T2DM.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77951989042&origin=inward; http://dx.doi.org/10.1309/lmubypdivgqwoy2u; https://academic.oup.com/labmed/article-lookup/doi/10.1309/LMUBYPDIVGQWOY2U; http://academic.oup.com/labmed/article-pdf/41/1/34/18682455/labmed41-0034.pdf; https://dx.doi.org/10.1309/lmubypdivgqwoy2u; https://academic.oup.com/labmed/article-abstract/41/1/34/2504870?redirectedFrom=fulltext
Oxford University Press (OUP)
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