Multi-parameter analysis using photovoltaic cell-based optofluidic cytometer
Biomedical Optics Express, ISSN: 2156-7085, Vol: 7, Issue: 9, Page: 3585-3595
2016
- 3Citations
- 7Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Article Description
A multi-parameter optofluidic cytometer based on two low-cost commercial photovoltaic cells and an avalanche photodetector is proposed. The optofluidic cytometer is fabricated on a polydimethylsiloxane (PDMS) substrate and is capable of detecting side scattered (SSC), extinction (EXT) and fluorescence (FL) signals simultaneously using a freespace light transmission technique without the need for on-chip optical waveguides. The feasibility of the proposed device is demonstrated by detecting fluorescent-labeled polystyrene beads with sizes of 3 μm, 5 μm and 10 μm, respectively, and label-free beads with a size of 7.26 μm. The detection experiments are performed using both single-bead population samples and mixed-bead population samples. The detection results obtained using the SSC/EXT, EXT/FL and SSC/FL signals are compared with those obtained using a commercial flow cytometer. It is shown that the optofluidic cytometer achieves a high detection accuracy for both single-bead population samples and mixed-bead population samples. Consequently, the proposed device provides a versatile, straightforward and lowcost solution for a wide variety of point-of-care (PoC) cytometry applications.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84989911071&origin=inward; http://dx.doi.org/10.1364/boe.7.003585; http://www.ncbi.nlm.nih.gov/pubmed/27699122; https://opg.optica.org/abstract.cfm?URI=boe-7-9-3585; https://www.osapublishing.org/abstract.cfm?URI=boe-7-9-3585; https://www.osapublishing.org/viewmedia.cfm?URI=boe-7-9-3585&seq=0; https://dx.doi.org/10.1364/boe.7.003585; https://opg.optica.org/boe/fulltext.cfm?uri=boe-7-9-3585&id=348961
Optica Publishing Group
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