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Tomographic molecular imaging of x-ray-excitable nanoparticles

Optics Letters, ISSN: 0146-9592, Vol: 35, Issue: 20, Page: 3345-3347
2010
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Article Description

X-ray luminescence computed tomography [XLCT] is proposed as a new dual molecular/anatomical imaging modality. XLCT is based on the selective excitation and optical detection of x-ray-excitable nanoparticles. As a proof of concept, we built a prototype XLCT system and imaged near-IR-emitting Gd OS:Eu phosphors in various phantoms. Imaging in an optically diffusive medium shows that imaging performance is not affected by optical scatter; furthermore, the linear response of the reconstructed images suggests that XLCT is capable of quantitative imaging. © 2010 Optical Society of America.

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