Quantitative evaluation of paracetamol and caffeine from pharmaceutical preparations using image analysis and RP-TLC
Chromatographia, ISSN: 1612-1112, Vol: 69, Issue: 1-2, Page: 151-155
2009
- 32Citations
- 25Captures
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Article Description
A reversed-phase high-performance thin-layer chromatographic method combined with image analysis was developed and validated for simultaneous quantitative evaluation of paracetamol and caffeine in pharmaceutical preparations. RP-HPTLC-W18 chromatographic plates were used as the stationary phase and methanol:glacial acetic acid:water (25:4.3:70.7; v:v:v) as the mobile phase. The detection of the spots and the image documentation were carried out under 254 nm UV radiation. Quantitative evaluation of the studied compounds was performed by Sorbfil TLC software. The proposed analytical method was characterized by good linearity, sustained by the correlation coefficient of 0.9974 for paracetamol and 0.9982 for caffeine. Limit of detection and limit of quantitation were found to be 0.100 and 0.191 μg spot, for paracetamol, as well as 0.040 and 0.076 μg spot, for caffeine. The results of the recovery studies are in the range of 99.56-106.84% and the repeatability of the method was shown to be excellent (RSD < 1.88%). © 2008 Vieweg+Teubner | GWV Fachverlage GmbH.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=58149464338&origin=inward; http://dx.doi.org/10.1365/s10337-008-0822-0; http://link.springer.com/10.1365/s10337-008-0822-0; https://link.springer.com/article/10.1365%2Fs10337-008-0822-0; http://www.springerlink.com/index/10.1365/s10337-008-0822-0; https://dx.doi.org/10.1365/s10337-008-0822-0; https://link.springer.com/article/10.1365/s10337-008-0822-0
Springer Science and Business Media LLC
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know