Pparγ2 is a key driver of longevity in the mouse
PLoS Genetics, ISSN: 1553-7390, Vol: 5, Issue: 12, Page: e1000752
2009
- 70Citations
- 91Captures
- 1Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations70
- Citation Indexes70
- 70
- CrossRef45
- Captures91
- Readers91
- 91
- Mentions1
- Blog Mentions1
- Blog1
Article Description
Aging involves a progressive physiological remodeling that is controlled by both genetic and environmental factors. Many of these factors impact also on white adipose tissue (WAT), which has been shown to be a determinant of lifespan. Interrogating a transcriptional network for predicted causal regulatory interactions in a collection of mouse WAT from F2 crosses with a seed set of 60 known longevity genes, we identified a novel transcriptional subnetwork of 742 genes which represent thus-far-unknown longevity genes. Within this subnetwork, one gene was Pparg (Nr1c3), an adipose-enriched nuclear receptor previously not associated with longevity. In silico, both the PPAR signaling pathway and the transcriptional signature of Pparγ agonist rosiglitazone overlapped with the longevity subnetwork, while in vivo, lowered expression of Pparg reduced lifespan in both the lipodystrophic Pparg1/2-hypomorphic and the Pparg2-deficient mice. These results establish Pparc2 as one of the determinants of longevity and suggest that lifespan may be rather determined by a purposeful genetic program than a random process. © 2009 Argmann et al.
Bibliographic Details
10.1371/journal.pgen.1000752; 10.1371/journal.pgen.1000752.t002; 10.1371/journal.pgen.1000752.g001; 10.1371/journal.pgen.1000752.t001; 10.1371/journal.pgen.1000752.g002
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=74249092870&origin=inward; http://dx.doi.org/10.1371/journal.pgen.1000752; http://www.ncbi.nlm.nih.gov/pubmed/19997628; https://dx.plos.org/10.1371/journal.pgen.1000752.t002; http://dx.doi.org/10.1371/journal.pgen.1000752.t002; https://dx.plos.org/10.1371/journal.pgen.1000752.g001; http://dx.doi.org/10.1371/journal.pgen.1000752.g001; https://dx.plos.org/10.1371/journal.pgen.1000752.t001; http://dx.doi.org/10.1371/journal.pgen.1000752.t001; https://dx.plos.org/10.1371/journal.pgen.1000752.g002; http://dx.doi.org/10.1371/journal.pgen.1000752.g002; https://dx.plos.org/10.1371/journal.pgen.1000752; https://dx.doi.org/10.1371/journal.pgen.1000752.t002; https://journals.plos.org/plosgenetics/article/figure?id=10.1371/journal.pgen.1000752.t002; https://dx.doi.org/10.1371/journal.pgen.1000752.t001; https://journals.plos.org/plosgenetics/article/figure?id=10.1371/journal.pgen.1000752.t001; https://dx.doi.org/10.1371/journal.pgen.1000752; https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1000752; https://dx.doi.org/10.1371/journal.pgen.1000752.g001; https://journals.plos.org/plosgenetics/article/figure?id=10.1371/journal.pgen.1000752.g001; https://dx.doi.org/10.1371/journal.pgen.1000752.g002; https://journals.plos.org/plosgenetics/article/figure?id=10.1371/journal.pgen.1000752.g002; http://dx.plos.org/10.1371/journal.pgen.1000752; https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000752&type=printable; http://www.plosgenetics.org/article/metrics/info:doi/10.1371/journal.pgen.1000752; http://journals.plos.org/plosgenetics/article?id=10.1371%2Fjournal.pgen.1000752; http://dx.plos.org/10.1371/journal.pgen.1000752.g002; http://dx.plos.org/10.1371/journal.pgen.1000752.t002; http://journals.plos.org/plosgenetics/article/metrics?id=10.1371/journal.pgen.1000752; http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1000752; http://www.plosone.org/article/metrics/info:doi/10.1371/journal.pgen.1000752; http://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000752&type=printable; http://dx.plos.org/10.1371/journal.pgen.1000752.g001; http://dx.plos.org/10.1371/journal.pgen.1000752.t001
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