Specification of drosophila corpora cardiaca neuroendocrine cells from mesoderm is regulated by notch signaling
PLoS Genetics, ISSN: 1553-7390, Vol: 7, Issue: 8, Page: e1002241
2011
- 18Citations
- 53Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations18
- Citation Indexes18
- 18
- CrossRef16
- Captures53
- Readers53
- 53
Article Description
Drosophila neuroendocrine cells comprising the corpora cardiaca (CC) are essential for systemic glucose regulation and represent functional orthologues of vertebrate pancreatic α-cells. Although Drosophila CC cells have been regarded as developmental orthologues of pituitary gland, the genetic regulation of CC development is poorly understood. From a genetic screen, we identified multiple novel regulators of CC development, including Notch signaling factors. Our studies demonstrate that the disruption of Notch signaling can lead to the expansion of CC cells. Live imaging demonstrates localized emergence of extra precursor cells as the basis of CC expansion in Notch mutants. Contrary to a recent report, we unexpectedly found that CC cells originate from head mesoderm. We show that Tinman expression in head mesoderm is regulated by Notch signaling and that the combination of Daughterless and Tinman is sufficient for ectopic CC specification in mesoderm. Understanding the cellular, genetic, signaling, and transcriptional basis of CC cell specification and expansion should accelerate discovery of molecular mechanisms regulating ontogeny of organs that control metabolism. © 2011 Park et al.
Bibliographic Details
10.1371/journal.pgen.1002241; 10.1371/journal.pgen.1002241.g006; 10.1371/journal.pgen.1002241.g007; 10.1371/journal.pgen.1002241.g002; 10.1371/journal.pgen.1002241.g005; 10.1371/journal.pgen.1002241.g003; 10.1371/journal.pgen.1002241.g001; 10.1371/journal.pgen.1002241.g004
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=80052330123&origin=inward; http://dx.doi.org/10.1371/journal.pgen.1002241; http://www.ncbi.nlm.nih.gov/pubmed/21901108; https://dx.plos.org/10.1371/journal.pgen.1002241.g006; http://dx.doi.org/10.1371/journal.pgen.1002241.g006; https://dx.plos.org/10.1371/journal.pgen.1002241.g007; http://dx.doi.org/10.1371/journal.pgen.1002241.g007; https://dx.plos.org/10.1371/journal.pgen.1002241; https://dx.plos.org/10.1371/journal.pgen.1002241.g002; http://dx.doi.org/10.1371/journal.pgen.1002241.g002; https://dx.plos.org/10.1371/journal.pgen.1002241.g005; http://dx.doi.org/10.1371/journal.pgen.1002241.g005; https://dx.plos.org/10.1371/journal.pgen.1002241.g003; http://dx.doi.org/10.1371/journal.pgen.1002241.g003; https://dx.plos.org/10.1371/journal.pgen.1002241.g001; http://dx.doi.org/10.1371/journal.pgen.1002241.g001; https://dx.plos.org/10.1371/journal.pgen.1002241.g004; http://dx.doi.org/10.1371/journal.pgen.1002241.g004; https://dx.doi.org/10.1371/journal.pgen.1002241.g005; https://journals.plos.org/plosgenetics/article/figure?id=10.1371/journal.pgen.1002241.g005; https://dx.doi.org/10.1371/journal.pgen.1002241.g004; https://journals.plos.org/plosgenetics/article/figure?id=10.1371/journal.pgen.1002241.g004; https://dx.doi.org/10.1371/journal.pgen.1002241.g001; https://journals.plos.org/plosgenetics/article/figure?id=10.1371/journal.pgen.1002241.g001; https://dx.doi.org/10.1371/journal.pgen.1002241.g003; https://journals.plos.org/plosgenetics/article/figure?id=10.1371/journal.pgen.1002241.g003; https://dx.doi.org/10.1371/journal.pgen.1002241; https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1002241; https://dx.doi.org/10.1371/journal.pgen.1002241.g002; https://journals.plos.org/plosgenetics/article/figure?id=10.1371/journal.pgen.1002241.g002; https://dx.doi.org/10.1371/journal.pgen.1002241.g007; https://journals.plos.org/plosgenetics/article/figure?id=10.1371/journal.pgen.1002241.g007; https://dx.doi.org/10.1371/journal.pgen.1002241.g006; https://journals.plos.org/plosgenetics/article/figure?id=10.1371/journal.pgen.1002241.g006; http://dx.plos.org/10.1371/journal.pgen.1002241.g001; http://dx.plos.org/10.1371/journal.pgen.1002241.g005; http://dx.plos.org/10.1371/journal.pgen.1002241.g006; http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1002241; https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002241&type=printable; http://dx.plos.org/10.1371/journal.pgen.1002241.g002; http://www.plosone.org/article/metrics/info:doi/10.1371/journal.pgen.1002241; http://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002241&type=printable; http://journals.plos.org/plosgenetics/article?id=10.1371%2Fjournal.pgen.1002241; http://dx.plos.org/10.1371/journal.pgen.1002241.g004; http://dx.plos.org/10.1371/journal.pgen.1002241.g007; http://dx.plos.org/10.1371/journal.pgen.1002241; http://dx.plos.org/10.1371/journal.pgen.1002241.g003
Public Library of Science (PLoS)
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know