Role of Bicaudal C1 in renal gluconeogenesis and its novel interaction with the CTLH complex
PLoS Genetics, ISSN: 1553-7404, Vol: 14, Issue: 7, Page: e1007487
2018
- 20Citations
- 44Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations20
- Citation Indexes20
- 20
- CrossRef18
- Captures44
- Readers44
- 44
Article Description
Altered glucose and lipid metabolism fuel cystic growth in polycystic kidneys, but the cause of these perturbations is unclear. Renal cysts also associate with mutations in Bicaudal C1 (Bicc1) or in its self-polymerizing sterile alpha motif (SAM). Here, we found that Bicc1 maintains normoglycemia and the expression of the gluconeogenic enzymes FBP1 and PEPCK in kidneys. A proteomic screen revealed that Bicc1 interacts with the C-Terminal to Lis-Homology domain (CTLH) complex. Since the orthologous Gid complex in S. cerevisae targets FBP1 and PEPCK for degradation, we mapped the topology among CTLH subunits and found that SAM-mediated binding controls Bicc1 protein levels, whereas Bicc1 inhibited the accumulation of several CTLH subunits. Under the conditions analyzed, Bicc1 increased FBP1 protein levels independently of the CTLH complex. Besides linking Bicc1 to cell metabolism, our findings reveal new layers of complexity in the regulation of renal gluconeogenesis compared to lower eukaryotes.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85050983058&origin=inward; http://dx.doi.org/10.1371/journal.pgen.1007487; http://www.ncbi.nlm.nih.gov/pubmed/29995892; https://dx.plos.org/10.1371/journal.pgen.1007487; https://dx.doi.org/10.1371/journal.pgen.1007487; https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007487
Public Library of Science (PLoS)
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