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TRAILS: Tree reconstruction of ancestry using incomplete lineage sorting

PLoS Genetics, ISSN: 1553-7404, Vol: 20, Issue: 2, Page: e1010836
2024
  • 1
    Citations
  • 0
    Usage
  • 12
    Captures
  • 1
    Mentions
  • 2
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    1
  • Captures
    12
  • Mentions
    1
    • News Mentions
      1
      • 1
  • Social Media
    2
    • Shares, Likes & Comments
      2
      • Facebook
        2

Most Recent News

Aarhus University Reports Findings in Engineering (TRAILS: Tree reconstruction of ancestry using incomplete lineage sorting)

2024 FEB 28 (NewsRx) -- By a News Reporter-Staff News Editor at Tech Daily News -- New research on Engineering is the subject of a

Article Description

Genome-wide genealogies of multiple species carry detailed information about demographic and selection processes on individual branches of the phylogeny. Here, we introduce TRAILS, a hidden Markov model that accurately infers time-resolved population genetics parameters, such as ancestral effective population sizes and speciation times, for ancestral branches using a multi-species alignment of three species and an outgroup. TRAILS leverages the information contained in incomplete lineage sorting fragments by modelling genealogies along the genome as rooted three-leaved trees, each with a topology and two coalescent events happening in discretized time intervals within the phylogeny. Posterior decoding of the hidden Markov model can be used to infer the ancestral recombination graph for the alignment and details on demographic changes within a branch. Since TRAILS performs posterior decoding at the base-pair level, genome-wide scans based on the posterior probabilities can be devised to detect deviations from neutrality. Using TRAILS on a human-chimp-gorilla-orangutan alignment, we recover speciation parameters and extract information about the topology and coalescent times at high resolution.

Bibliographic Details

Iker Rivas-González; Mikkel H. Schierup; John Wakeley; Asger Hobolth; Pier Francesco Palamara

Public Library of Science (PLoS)

Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology; Medicine

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