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Vasomotion and neurovascular coupling in the visual thalamus in vivo

PLoS ONE, ISSN: 1932-6203, Vol: 6, Issue: 12, Page: e28746
2011
  • 31
    Citations
  • 0
    Usage
  • 52
    Captures
  • 0
    Mentions
  • 45
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    31
  • Captures
    52
  • Social Media
    45
    • Shares, Likes & Comments
      45
      • Facebook
        45

Article Description

Spontaneous contraction and relaxation of arteries (and in some instances venules) has been termed vasomotion and has been observed in an extensive variety of tissues and species. However, its functions and underlying mechanisms are still under discussion. We demonstrate that in vivo spectrophotometry, measured simultaneously with extracellular recordings at the same locations in the visual thalamus of the cat, reveals vasomotion, measured as an oscillation (0.14hz) in the recorded oxyhemoglobin (OxyHb) signal, which appears spontaneously in the microcirculation and can last for periods of hours. During some non-oscillatory periods, maintained sensory stimulation evokes vasomotion lasting ~30s, resembling an adaptive vascular phenomenon. This oscillation in the oxyhaemoblobin signal is sensitive to pharmacological manipulation: it is inducible by chloralose anaesthesia and it can be temporarily blocked by systemic administration of adrenaline or acetylcholine (ACh). During these oscillatory periods, neurovascular coupling (i.e. the relationship between local neural activity and the rate of blood supply to that location) appears significantly altered. This raises important questions with regard to the interpretation of results from studies currently dependent upon a linear relationship between neural activity and blood flow, such as neuroimaging. © 2011 Rivadulla et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Bibliographic Details

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Casto Rivadulla; Carmen de Labra; Kenneth L. Grieve; Javier Cudeiro; Clayton T. Dickson

Public Library of Science (PLoS)

Biochemistry, Genetics and Molecular Biology; Agricultural and Biological Sciences; Multidisciplinary

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