Altered neural and behavioral dynamics in Huntington's disease: An entropy conservation approach
PLoS ONE, ISSN: 1932-6203, Vol: 7, Issue: 1, Page: e30879
2012
- 16Citations
- 43Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations16
- Citation Indexes16
- 16
- CrossRef9
- Captures43
- Readers43
- 43
Article Description
Background: Huntington's disease (HD) is an inherited condition that results in neurodegeneration of the striatum, the forebrain structure that processes cortical information for behavioral output. In the R6/2 transgenic mouse model of HD, striatal neurons exhibit aberrant firing patterns that are coupled with reduced flexibility in the motor system. The aim of this study was to test the patterns of unpredictability in brain and behavior in wild-type (WT) and R6/2 mice. Methodology/Principal Findings: Striatal local field potentials (LFP) were recorded from 18 WT and 17 R6/2 mice (aged 8-11 weeks) while the mice were exploring a plus-shaped maze. We targeted LFP activity for up to 2 s before and 2 s after each choice-point entry. Approximate Entropy (ApEn) was calculated for LFPs and Shannon Entropy was used to measure the probability of arm choice, as well as the likelihood of making consecutive 90-degree turns in the maze. We found that although the total number of choice-point crossings and entropy of arm-choice probability was similar in both groups, R6/2 mice had more predictable behavioral responses (i.e., were less likely to make 90-degree turns and perform them in alternation with running straight down the same arm), while exhibiting more unpredictable striatal activity, as indicated by higher ApEn values. In both WT and R6/2 mice, however, behavioral unpredictability was negatively correlated with LFP ApEn. Conclusions/Significance: HD results in a perseverative exploration of the environment, occurring in concert with more unpredictable brain activity. Our results support the entropy conservation hypothesis in which unpredictable behavioral patterns are coupled with more predictable brain activation patterns, suggesting that this may be a fundamental process unaffected by HD. © 2012 Hong et al.
Bibliographic Details
10.1371/journal.pone.0030879; 10.1371/journal.pone.0030879.g003; 10.1371/journal.pone.0030879.g004; 10.1371/journal.pone.0030879.g005; 10.1371/journal.pone.0030879.g002; 10.1371/journal.pone.0030879.g001; 10.1371/journal.pone.0030879.g006; 10.1371/journal.pone.0030879.t001
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84856092676&origin=inward; http://dx.doi.org/10.1371/journal.pone.0030879; http://www.ncbi.nlm.nih.gov/pubmed/22292068; https://dx.plos.org/10.1371/journal.pone.0030879.g003; http://dx.doi.org/10.1371/journal.pone.0030879.g003; https://dx.plos.org/10.1371/journal.pone.0030879.g004; http://dx.doi.org/10.1371/journal.pone.0030879.g004; https://dx.plos.org/10.1371/journal.pone.0030879.g005; http://dx.doi.org/10.1371/journal.pone.0030879.g005; https://dx.plos.org/10.1371/journal.pone.0030879.g002; http://dx.doi.org/10.1371/journal.pone.0030879.g002; https://dx.plos.org/10.1371/journal.pone.0030879.g001; http://dx.doi.org/10.1371/journal.pone.0030879.g001; https://dx.plos.org/10.1371/journal.pone.0030879.g006; http://dx.doi.org/10.1371/journal.pone.0030879.g006; https://dx.plos.org/10.1371/journal.pone.0030879.t001; http://dx.doi.org/10.1371/journal.pone.0030879.t001; https://dx.plos.org/10.1371/journal.pone.0030879; https://dx.doi.org/10.1371/journal.pone.0030879.g002; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0030879.g002; https://dx.doi.org/10.1371/journal.pone.0030879.t001; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0030879.t001; https://dx.doi.org/10.1371/journal.pone.0030879; https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0030879; https://dx.doi.org/10.1371/journal.pone.0030879.g005; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0030879.g005; https://dx.doi.org/10.1371/journal.pone.0030879.g001; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0030879.g001; https://dx.doi.org/10.1371/journal.pone.0030879.g003; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0030879.g003; https://dx.doi.org/10.1371/journal.pone.0030879.g006; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0030879.g006; https://dx.doi.org/10.1371/journal.pone.0030879.g004; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0030879.g004; http://www.plosone.org/article/metrics/info:doi/10.1371/journal.pone.0030879; http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0030879&type=printable; http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0030879; http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0030879; https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0030879&type=printable; http://dx.plos.org/10.1371/journal.pone.0030879.g001; http://dx.plos.org/10.1371/journal.pone.0030879.g005; http://dx.plos.org/10.1371/journal.pone.0030879; http://dx.plos.org/10.1371/journal.pone.0030879.g004; http://dx.plos.org/10.1371/journal.pone.0030879.g002; http://dx.plos.org/10.1371/journal.pone.0030879.t001; http://dx.plos.org/10.1371/journal.pone.0030879.g006; http://dx.plos.org/10.1371/journal.pone.0030879.g003
Public Library of Science (PLoS)
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know