Cell cycle dependent association of EBP50 with protein phosphatase 2A in endothelial cells
PLoS ONE, ISSN: 1932-6203, Vol: 7, Issue: 4, Page: e35595
2012
- 13Citations
- 19Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations13
- Citation Indexes13
- 13
- CrossRef8
- Captures19
- Readers19
- 19
Article Description
Ezrin-radixin-moesin (ERM)-binding phosphoprotein 50 (EBP50) is a phosphorylatable PDZ domain-containing adaptor protein that is abundantly expressed in epithelium but was not yet studied in the endothelium. We report unusual nuclear localization of EBP50 in bovine pulmonary artery endothelial cells (BPAEC). Immunofluorescent staining and cellular fractionation demonstrated that EBP50 is present in the nuclear and perinuclear region in interphase cells. In the prophase of mitosis EBP50 redistributes to the cytoplasmic region in a phosphorylation dependent manner and during mitosis EBP50 co-localizes with protein phosphatase 2A (PP2A). Furthermore, in vitro wound healing of BPAEC expressing phospho-mimic mutant of EBP50 was accelerated indicating that EBP50 is involved in the regulation of the cell division. Cell cycle dependent specific interactions were detected between EBP50 and the subunits of PP2A (A, C, and Bα) with immunoprecipitation and pull-down experiments. The interaction of EBP50 with the Bα containing form of PP2A suggests that this holoenzyme of PP2A can be responsible for the dephosphorylation of EBP50 in cytokinesis. Moreover, the results underline the significance of EBP50 in cell division via reversible phosphorylation of the protein with cyclin dependent kinase and PP2A in normal cells. © 2012 Boratkó et al.
Bibliographic Details
10.1371/journal.pone.0035595; 10.1371/journal.pone.0035595.g002; 10.1371/journal.pone.0035595.g007; 10.1371/journal.pone.0035595.g001; 10.1371/journal.pone.0035595.g004; 10.1371/journal.pone.0035595.g005; 10.1371/journal.pone.0035595.g006; 10.1371/journal.pone.0035595.g003
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84859867097&origin=inward; http://dx.doi.org/10.1371/journal.pone.0035595; http://www.ncbi.nlm.nih.gov/pubmed/22523604; https://dx.plos.org/10.1371/journal.pone.0035595.g002; http://dx.doi.org/10.1371/journal.pone.0035595.g002; https://dx.plos.org/10.1371/journal.pone.0035595.g007; http://dx.doi.org/10.1371/journal.pone.0035595.g007; https://dx.plos.org/10.1371/journal.pone.0035595.g001; http://dx.doi.org/10.1371/journal.pone.0035595.g001; https://dx.plos.org/10.1371/journal.pone.0035595.g004; http://dx.doi.org/10.1371/journal.pone.0035595.g004; https://dx.plos.org/10.1371/journal.pone.0035595.g005; http://dx.doi.org/10.1371/journal.pone.0035595.g005; https://dx.plos.org/10.1371/journal.pone.0035595.g006; http://dx.doi.org/10.1371/journal.pone.0035595.g006; https://dx.plos.org/10.1371/journal.pone.0035595; https://dx.plos.org/10.1371/journal.pone.0035595.g003; http://dx.doi.org/10.1371/journal.pone.0035595.g003; https://dx.doi.org/10.1371/journal.pone.0035595.g002; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0035595.g002; https://dx.doi.org/10.1371/journal.pone.0035595.g001; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0035595.g001; https://dx.doi.org/10.1371/journal.pone.0035595; https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0035595; https://dx.doi.org/10.1371/journal.pone.0035595.g005; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0035595.g005; https://dx.doi.org/10.1371/journal.pone.0035595.g003; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0035595.g003; https://dx.doi.org/10.1371/journal.pone.0035595.g004; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0035595.g004; https://dx.doi.org/10.1371/journal.pone.0035595.g007; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0035595.g007; https://dx.doi.org/10.1371/journal.pone.0035595.g006; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0035595.g006; http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0035595; https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0035595&type=printable; http://dx.plos.org/10.1371/journal.pone.0035595.g004; http://www.plosone.org/article/metrics/info:doi/10.1371/journal.pone.0035595; http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0035595&type=printable; http://dx.plos.org/10.1371/journal.pone.0035595.g007; http://dx.plos.org/10.1371/journal.pone.0035595.g001; http://dx.plos.org/10.1371/journal.pone.0035595.g002; http://dx.plos.org/10.1371/journal.pone.0035595.g005; http://dx.plos.org/10.1371/journal.pone.0035595; http://dx.plos.org/10.1371/journal.pone.0035595.g003; http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0035595; http://dx.plos.org/10.1371/journal.pone.0035595.g006
Public Library of Science (PLoS)
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know