Ovariectomy Induces a Shift in Fuel Availability and Metabolism in the Hippocampus of the Female Transgenic Model of Familial Alzheimer's
PLoS ONE, ISSN: 1932-6203, Vol: 8, Issue: 3, Page: e59825
2013
- 69Citations
- 88Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations69
- Citation Indexes69
- 69
- CrossRef34
- Captures88
- Readers88
- 88
Article Description
Previously, we demonstrated that reproductive senescence in female triple transgenic Alzheimer's (3×TgAD) mice was paralleled by a shift towards a ketogenic profile with a concomitant decline in mitochondrial activity in brain, suggesting a potential association between ovarian hormone loss and alteration in the bioenergetic profile of the brain. In the present study, we investigated the impact of ovariectomy and 17β-estradiol replacement on brain energy substrate availability and metabolism in a mouse model of familial Alzheimer's (3×TgAD). Results of these analyses indicated that ovarian hormones deprivation by ovariectomy (OVX) induced a significant decrease in brain glucose uptake indicated by decline in 2-[F]fluoro-2-deoxy-D-glucose uptake measured by microPET-imaging. Mechanistically, OVX induced a significant decline in blood-brain-barrier specific glucose transporter expression, hexokinase expression and activity. The decline in glucose availability was accompanied by a significant rise in glial LDH5 expression and LDH5/LDH1 ratio indicative of lactate generation and utilization. In parallel, a significant rise in ketone body concentration in serum occurred which was coupled to an increase in neuronal MCT2 expression and 3-oxoacid-CoA transferase (SCOT) required for conversion of ketone bodies to acetyl-CoA. In addition, OVX-induced decline in glucose metabolism was paralleled by a significant increase in Aβ oligomer levels. 17β-estradiol preserved brain glucose-driven metabolic capacity and partially prevented the OVX-induced shift in bioenergetic substrate as evidenced by glucose uptake, glucose transporter expression and gene expression associated with aerobic glycolysis. 17β-estradiol also partially prevented the OVX-induced increase in Aβ oligomer levels. Collectively, these data indicate that ovarian hormone loss in a preclinical model of Alzheimer's was paralleled by a shift towards the metabolic pathway required for metabolism of alternative fuels in brain with a concomitant decline in brain glucose transport and metabolism. These findings also indicate that estrogen plays a critical role in sustaining brain bioenergetic capacity through preservation of glucose metabolism. © 2013 Ding et al.
Bibliographic Details
10.1371/journal.pone.0059825; 10.1371/journal.pone.0059825.g007; 10.1371/journal.pone.0059825.g003; 10.1371/journal.pone.0059825.g008; 10.1371/journal.pone.0059825.g004; 10.1371/journal.pone.0059825.g002; 10.1371/journal.pone.0059825.g001; 10.1371/journal.pone.0059825.g006; 10.1371/journal.pone.0059825.g009; 10.1371/journal.pone.0059825.g005
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84875423210&origin=inward; http://dx.doi.org/10.1371/journal.pone.0059825; http://www.ncbi.nlm.nih.gov/pubmed/23555795; https://dx.plos.org/10.1371/journal.pone.0059825.g007; http://dx.doi.org/10.1371/journal.pone.0059825.g007; https://dx.plos.org/10.1371/journal.pone.0059825.g003; http://dx.doi.org/10.1371/journal.pone.0059825.g003; https://dx.plos.org/10.1371/journal.pone.0059825.g008; http://dx.doi.org/10.1371/journal.pone.0059825.g008; https://dx.plos.org/10.1371/journal.pone.0059825.g004; http://dx.doi.org/10.1371/journal.pone.0059825.g004; https://dx.plos.org/10.1371/journal.pone.0059825.g002; http://dx.doi.org/10.1371/journal.pone.0059825.g002; https://dx.plos.org/10.1371/journal.pone.0059825; https://dx.plos.org/10.1371/journal.pone.0059825.g001; http://dx.doi.org/10.1371/journal.pone.0059825.g001; https://dx.plos.org/10.1371/journal.pone.0059825.g006; http://dx.doi.org/10.1371/journal.pone.0059825.g006; https://dx.plos.org/10.1371/journal.pone.0059825.g009; http://dx.doi.org/10.1371/journal.pone.0059825.g009; https://dx.plos.org/10.1371/journal.pone.0059825.g005; http://dx.doi.org/10.1371/journal.pone.0059825.g005; https://dx.doi.org/10.1371/journal.pone.0059825.g003; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0059825.g003; https://dx.doi.org/10.1371/journal.pone.0059825.g002; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0059825.g002; https://dx.doi.org/10.1371/journal.pone.0059825.g005; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0059825.g005; https://dx.doi.org/10.1371/journal.pone.0059825.g006; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0059825.g006; https://dx.doi.org/10.1371/journal.pone.0059825.g008; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0059825.g008; https://dx.doi.org/10.1371/journal.pone.0059825.g001; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0059825.g001; https://dx.doi.org/10.1371/journal.pone.0059825.g004; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0059825.g004; https://dx.doi.org/10.1371/journal.pone.0059825.g007; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0059825.g007; https://dx.doi.org/10.1371/journal.pone.0059825; https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0059825; https://dx.doi.org/10.1371/journal.pone.0059825.g009; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0059825.g009; http://dx.plos.org/10.1371/journal.pone.0059825.g004; http://dx.plos.org/10.1371/journal.pone.0059825; https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0059825&type=printable; http://www.plosone.org/article/metrics/info:doi/10.1371/journal.pone.0059825; http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0059825&type=printable; http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0059825; http://dx.plos.org/10.1371/journal.pone.0059825.g005; http://dx.plos.org/10.1371/journal.pone.0059825.g003; http://dx.plos.org/10.1371/journal.pone.0059825.g006; http://dx.plos.org/10.1371/journal.pone.0059825.g001; http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0059825; http://dx.plos.org/10.1371/journal.pone.0059825.g007; http://dx.plos.org/10.1371/journal.pone.0059825.g008; http://dx.plos.org/10.1371/journal.pone.0059825.g002; http://dx.plos.org/10.1371/journal.pone.0059825.g009
Public Library of Science (PLoS)
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know