PlumX Metrics
Embed PlumX Metrics

Differential effects of antibiotic therapy on the structure and function of human gut microbiota

PLoS ONE, ISSN: 1932-6203, Vol: 8, Issue: 11, Page: e80201
2013
  • 168
    Citations
  • 0
    Usage
  • 349
    Captures
  • 0
    Mentions
  • 13
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    168
  • Captures
    349
  • Social Media
    13
    • Shares, Likes & Comments
      13
      • Facebook
        13

Article Description

The human intestinal microbiota performs many essential functions for the host. Antimicrobial agents, such as antibiotics (AB), are also known to disturb microbial community equilibrium, thereby having an impact on human physiology. While an increasing number of studies investigate the effects of AB usage on changes in human gut microbiota biodiversity, its functional effects are still poorly understood. We performed a follow-up study to explore the effect of ABs with different modes of action on human gut microbiota composition and function. Four individuals were treated with different antibiotics and samples were taken before, during and after the AB course for all of them. Changes in the total and in the active (growing) microbiota as well as the functional changes were addressed by 16S rRNA gene and metagenomic 454-based pyrosequencing approaches. We have found that the class of antibiotic, particularly its antimicrobial effect and mode of action, played an important role in modulating the gut microbiota composition and function. Furthermore, analysis of the resistome suggested that oscillatory dynamics are not only due to antibiotic-target resistance, but also to fluctuations in the surviving bacterial community. Our results indicated that the effect of AB on the human gut microbiota relates to the interaction of several factors, principally the properties of the antimicrobial agent, and the structure, functions and resistance genes of the microbial community. © 2013 Pérez-Cobas et al.

Bibliographic Details

http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84894268743&origin=inward; http://dx.doi.org/10.1371/journal.pone.0080201; http://www.ncbi.nlm.nih.gov/pubmed/24282523; https://dx.plos.org/10.1371/journal.pone.0080201; https://dx.plos.org/10.1371/journal.pone.0080201.g002; http://dx.doi.org/10.1371/journal.pone.0080201.g002; https://dx.plos.org/10.1371/journal.pone.0080201.g003; http://dx.doi.org/10.1371/journal.pone.0080201.g003; https://dx.plos.org/10.1371/journal.pone.0080201.t002; http://dx.doi.org/10.1371/journal.pone.0080201.t002; https://dx.plos.org/10.1371/journal.pone.0080201.t001; http://dx.doi.org/10.1371/journal.pone.0080201.t001; https://dx.plos.org/10.1371/journal.pone.0080201.g004; http://dx.doi.org/10.1371/journal.pone.0080201.g004; https://dx.plos.org/10.1371/journal.pone.0080201.g001; http://dx.doi.org/10.1371/journal.pone.0080201.g001; https://dx.doi.org/10.1371/journal.pone.0080201.g004; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0080201.g004; https://dx.doi.org/10.1371/journal.pone.0080201.t002; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0080201.t002; https://dx.doi.org/10.1371/journal.pone.0080201; https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0080201; https://dx.doi.org/10.1371/journal.pone.0080201.g001; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0080201.g001; https://dx.doi.org/10.1371/journal.pone.0080201.g002; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0080201.g002; https://dx.doi.org/10.1371/journal.pone.0080201.g003; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0080201.g003; https://dx.doi.org/10.1371/journal.pone.0080201.t001; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0080201.t001; https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0080201&type=printable; http://dx.plos.org/10.1371/journal.pone.0080201.t001; http://dx.plos.org/10.1371/journal.pone.0080201.g002; http://www.plosone.org/article/metrics/info:doi/10.1371/journal.pone.0080201; http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0080201&type=printable; http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0080201; http://dx.plos.org/10.1371/journal.pone.0080201.g003; http://dx.plos.org/10.1371/journal.pone.0080201.g004; http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0080201; http://dx.plos.org/10.1371/journal.pone.0080201.t002; http://dx.plos.org/10.1371/journal.pone.0080201.g001; http://dx.plos.org/10.1371/journal.pone.0080201

Ana Elena Pérez-Cobas; Alejandro Artacho; Henrik Knecht; María Loreto Ferrús; Anette Friedrichs; Stephan J. Ott; Andrés Moya; Amparo Latorre; María José Gosalbes; Ramy K. Aziz

Public Library of Science (PLoS)

Multidisciplinary

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know