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Repetitive long-term Hyperbaric Oxygen Treatment,(HBOT)administered after experimental traumatic brain injury in rats induces significant remyelination and a recovery of sensorimotor function

PLoS ONE, ISSN: 1932-6203, Vol: 9, Issue: 5, Page: e97750
2014
  • 27
    Citations
  • 0
    Usage
  • 64
    Captures
  • 0
    Mentions
  • 32
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    27
  • Captures
    64
  • Social Media
    32
    • Shares, Likes & Comments
      32
      • Facebook
        32

Article Description

Cells in the central nervous system rely almost exclusively on aerobic metabolism. Oxygen deprivation, such as injury-associated ischemia, results in detrimental apoptotic and necrotic cell loss. There is evidence that repetitive hyperbaric oxygen therapy (HBOT) improves outcomes in traumatic brain-injured patients. However, there are no experimental studies investigating the mechanism of repetitive long-term HBOT treatment-associated protective effects. We have therefore analysed the effect of long-term repetitive HBOT treatment on brain trauma-associated cerebral modulations using the lateral fluid percussion model for rats. Trauma-associated neurological impairment regressed significantly in the group of HBO-treated animals within three weeks post trauma. Evaluation of somatosensory-evoked potentials indicated a possible remyelination of neurons in the injured hemisphere following HBOT. This presumption was confirmed by a pronounced increase in myelin basic protein isoforms, PLP expression as well as an increase in myelin following three weeks of repetitive HBO treatment. Our results indicate that protective long-term HBOT effects following brain injury is mediated by a pronounced remyelination in the ipsilateral injured cortex as substantiated by the associated recovery of sensorimotor function. © 2014 Kraitsy et al.

Bibliographic Details

http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84901364347&origin=inward; http://dx.doi.org/10.1371/journal.pone.0097750; http://www.ncbi.nlm.nih.gov/pubmed/24848795; https://dx.plos.org/10.1371/journal.pone.0097750.g003; http://dx.doi.org/10.1371/journal.pone.0097750.g003; https://dx.plos.org/10.1371/journal.pone.0097750.g006; http://dx.doi.org/10.1371/journal.pone.0097750.g006; https://dx.plos.org/10.1371/journal.pone.0097750.t001; http://dx.doi.org/10.1371/journal.pone.0097750.t001; https://dx.plos.org/10.1371/journal.pone.0097750.g002; http://dx.doi.org/10.1371/journal.pone.0097750.g002; https://dx.plos.org/10.1371/journal.pone.0097750.g004; http://dx.doi.org/10.1371/journal.pone.0097750.g004; https://dx.plos.org/10.1371/journal.pone.0097750.g001; http://dx.doi.org/10.1371/journal.pone.0097750.g001; https://dx.plos.org/10.1371/journal.pone.0097750; https://dx.plos.org/10.1371/journal.pone.0097750.g005; http://dx.doi.org/10.1371/journal.pone.0097750.g005; https://dx.doi.org/10.1371/journal.pone.0097750.g004; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0097750.g004; https://dx.doi.org/10.1371/journal.pone.0097750; https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0097750; https://dx.doi.org/10.1371/journal.pone.0097750.g006; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0097750.g006; https://dx.doi.org/10.1371/journal.pone.0097750.g003; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0097750.g003; https://dx.doi.org/10.1371/journal.pone.0097750.t001; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0097750.t001; https://dx.doi.org/10.1371/journal.pone.0097750.g001; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0097750.g001; https://dx.doi.org/10.1371/journal.pone.0097750.g002; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0097750.g002; https://dx.doi.org/10.1371/journal.pone.0097750.g005; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0097750.g005; http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0097750; https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0097750&type=printable; http://dx.plos.org/10.1371/journal.pone.0097750.g005; http://dx.plos.org/10.1371/journal.pone.0097750; http://www.plosone.org/article/metrics/info:doi/10.1371/journal.pone.0097750; http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0097750&type=printable; http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0097750; http://dx.plos.org/10.1371/journal.pone.0097750.g003; http://dx.plos.org/10.1371/journal.pone.0097750.g001; http://dx.plos.org/10.1371/journal.pone.0097750.g006; http://dx.plos.org/10.1371/journal.pone.0097750.g004; http://dx.plos.org/10.1371/journal.pone.0097750.t001; http://dx.plos.org/10.1371/journal.pone.0097750.g002

Klaus Kraitsy; Muammer Uecal; Stefan Grossauer; Lukas Bruckmann; Florentina Pfleger; Stefan Ropele; Franz Fazekas; Gerda Gruenbacher; Silke Patz; Markus Absenger; Christian Porubsky; Freyja Smolle-Juettner; Irem Tezer; Marek Molcanyi; Ulrike Fasching; Ute Schaefer; Raghavan Raju

Public Library of Science (PLoS)

Multidisciplinary

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