Repetitive long-term Hyperbaric Oxygen Treatment,(HBOT)administered after experimental traumatic brain injury in rats induces significant remyelination and a recovery of sensorimotor function
PLoS ONE, ISSN: 1932-6203, Vol: 9, Issue: 5, Page: e97750
2014
- 27Citations
- 64Captures
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Metrics Details
- Citations27
- Citation Indexes27
- 27
- CrossRef13
- Captures64
- Readers64
- 64
Article Description
Cells in the central nervous system rely almost exclusively on aerobic metabolism. Oxygen deprivation, such as injury-associated ischemia, results in detrimental apoptotic and necrotic cell loss. There is evidence that repetitive hyperbaric oxygen therapy (HBOT) improves outcomes in traumatic brain-injured patients. However, there are no experimental studies investigating the mechanism of repetitive long-term HBOT treatment-associated protective effects. We have therefore analysed the effect of long-term repetitive HBOT treatment on brain trauma-associated cerebral modulations using the lateral fluid percussion model for rats. Trauma-associated neurological impairment regressed significantly in the group of HBO-treated animals within three weeks post trauma. Evaluation of somatosensory-evoked potentials indicated a possible remyelination of neurons in the injured hemisphere following HBOT. This presumption was confirmed by a pronounced increase in myelin basic protein isoforms, PLP expression as well as an increase in myelin following three weeks of repetitive HBO treatment. Our results indicate that protective long-term HBOT effects following brain injury is mediated by a pronounced remyelination in the ipsilateral injured cortex as substantiated by the associated recovery of sensorimotor function. © 2014 Kraitsy et al.
Bibliographic Details
10.1371/journal.pone.0097750; 10.1371/journal.pone.0097750.g003; 10.1371/journal.pone.0097750.g006; 10.1371/journal.pone.0097750.t001; 10.1371/journal.pone.0097750.g002; 10.1371/journal.pone.0097750.g004; 10.1371/journal.pone.0097750.g001; 10.1371/journal.pone.0097750.g005
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