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Epigenetic inheritance, epimutation, and the response to selection

PLoS ONE, ISSN: 1932-6203, Vol: 9, Issue: 7, Page: e101559
2014
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Article Description

There has been minimal theoretical exploration of the role of epigenetic variation in the response to natural selection. Using a population genetic model, I derive formulae that characterize the response of epigenetic variation to selection over multiple generations. Unlike genetic models in which mutation rates are assumed to be low relative to the strength of selection, the response to selection decays quickly due to a rapid lowering of parent-offspring epiallelic correlation. This effect is separate from the slowing response caused by a reduction in epigenetic variation. These results suggest that epigenetic variation may be less responsive to natural selection than is genetic variation, even in cases where levels of heritability appear similar. © 2014 Robert E. Furrow.

Bibliographic Details

http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84904248315&origin=inward; http://dx.doi.org/10.1371/journal.pone.0101559; http://www.ncbi.nlm.nih.gov/pubmed/25019291; https://dx.plos.org/10.1371/journal.pone.0101559; https://dx.plos.org/10.1371/journal.pone.0101559.g002; http://dx.doi.org/10.1371/journal.pone.0101559.g002; https://dx.plos.org/10.1371/journal.pone.0101559.t001; http://dx.doi.org/10.1371/journal.pone.0101559.t001; https://dx.plos.org/10.1371/journal.pone.0101559.g001; http://dx.doi.org/10.1371/journal.pone.0101559.g001; https://dx.doi.org/10.1371/journal.pone.0101559.g001; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0101559.g001; https://dx.doi.org/10.1371/journal.pone.0101559.g002; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0101559.g002; https://dx.doi.org/10.1371/journal.pone.0101559.t001; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0101559.t001; https://dx.doi.org/10.1371/journal.pone.0101559; https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0101559; http://www.plosone.org/article/metrics/info:doi/10.1371/journal.pone.0101559; http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0101559&type=printable; http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0101559; http://dx.plos.org/10.1371/journal.pone.0101559.g002; https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0101559&type=printable; http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0101559; http://dx.plos.org/10.1371/journal.pone.0101559.t001; http://dx.plos.org/10.1371/journal.pone.0101559.g001; http://dx.plos.org/10.1371/journal.pone.0101559

Robert E. Furrow; Lilach Hadany

Public Library of Science (PLoS)

Biochemistry, Genetics and Molecular Biology; Agricultural and Biological Sciences; Multidisciplinary

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