A whole recombinant yeast-based therapeutic vaccine elicits HBV X, S and core specific T cells in mice and activates human T cells recognizing epitopes linked to viral clearance
PLoS ONE, ISSN: 1932-6203, Vol: 9, Issue: 7, Page: e101904
2014
- 61Citations
- 71Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations61
- Citation Indexes58
- CrossRef58
- 57
- Clinical Citations1
- PubMed Guidelines1
- Patent Family Citations1
- Patent Families1
- Policy Citations1
- Policy Citation1
- Captures71
- Readers71
- 71
Article Description
Chronic hepatitis B infection (CHB) is characterized by sub-optimal T cell responses to viral antigens. A therapeutic vaccine capable of restoring these immune responses could potentially improve HBsAg seroconversion rates in the setting of direct acting antiviral therapies. A yeast-based immunotherapy (Tarmogen) platform was used to make a vaccine candidate expressing hepatitis B virus (HBV) X, surface (S), and Core antigens (X-S-Core). Murine and human immunogenicity models were used to evaluate the type and magnitude of HBV-Ag specific T cell responses elicited by the vaccine. C57BL/6J, BALB/c, and HLA-A*0201 transgenic mice immunized with yeast expressing X-S-Core showed T cell responses to X, S and Core when evaluated by lymphocyte proliferation assay, ELISpot, intracellular cytokine staining (ICS), or tumor challenge assays. Both CD4 and CD8 T cell responses were observed. Human T cells transduced with HBc18-27 and HBs183-91 specific T cell receptors (TCRs) produced interferon gamma (IFNγ following incubation with X-S-Core-pulsed dendritic cells (DCs). Furthermore, stimulation of peripheral blood mononuclear cells (PBMCs) isolated from CHB patients or from HBV vaccine recipients with autologous DCs pulsed with X-S-Core or a related product (S-Core) resulted in pronounced expansions of HBV Ag-specific T cells possessing a cytolytic phenotype. These data indicate that X-S-Core-expressing yeast elicit functional adaptive immune responses and supports the ongoing evaluation of this therapeutic vaccine in patients with CHB to enhance the induction of HBV-specific T cell responses. © 2014 King et al.
Bibliographic Details
10.1371/journal.pone.0101904; 10.1371/journal.pone.0101904.g006; 10.1371/journal.pone.0101904.t002; 10.1371/journal.pone.0101904.g003; 10.1371/journal.pone.0101904.g004; 10.1371/journal.pone.0101904.g005; 10.1371/journal.pone.0101904.t001; 10.1371/journal.pone.0101904.g001; 10.1371/journal.pone.0101904.g008; 10.1371/journal.pone.0101904.g007; 10.1371/journal.pone.0101904.g002
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84904625418&origin=inward; http://dx.doi.org/10.1371/journal.pone.0101904; http://www.ncbi.nlm.nih.gov/pubmed/25051027; https://dx.plos.org/10.1371/journal.pone.0101904.g006; http://dx.doi.org/10.1371/journal.pone.0101904.g006; https://dx.plos.org/10.1371/journal.pone.0101904.t002; http://dx.doi.org/10.1371/journal.pone.0101904.t002; https://dx.plos.org/10.1371/journal.pone.0101904.g003; http://dx.doi.org/10.1371/journal.pone.0101904.g003; https://dx.plos.org/10.1371/journal.pone.0101904.g004; http://dx.doi.org/10.1371/journal.pone.0101904.g004; https://dx.plos.org/10.1371/journal.pone.0101904; https://dx.plos.org/10.1371/journal.pone.0101904.g005; http://dx.doi.org/10.1371/journal.pone.0101904.g005; https://dx.plos.org/10.1371/journal.pone.0101904.t001; http://dx.doi.org/10.1371/journal.pone.0101904.t001; https://dx.plos.org/10.1371/journal.pone.0101904.g001; http://dx.doi.org/10.1371/journal.pone.0101904.g001; https://dx.plos.org/10.1371/journal.pone.0101904.g008; http://dx.doi.org/10.1371/journal.pone.0101904.g008; https://dx.plos.org/10.1371/journal.pone.0101904.g007; http://dx.doi.org/10.1371/journal.pone.0101904.g007; https://dx.plos.org/10.1371/journal.pone.0101904.g002; http://dx.doi.org/10.1371/journal.pone.0101904.g002; https://dx.doi.org/10.1371/journal.pone.0101904.g004; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0101904.g004; https://dx.doi.org/10.1371/journal.pone.0101904.g006; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0101904.g006; https://dx.doi.org/10.1371/journal.pone.0101904.g002; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0101904.g002; https://dx.doi.org/10.1371/journal.pone.0101904; https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0101904; https://dx.doi.org/10.1371/journal.pone.0101904.g003; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0101904.g003; https://dx.doi.org/10.1371/journal.pone.0101904.g008; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0101904.g008; https://dx.doi.org/10.1371/journal.pone.0101904.t001; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0101904.t001; https://dx.doi.org/10.1371/journal.pone.0101904.t002; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0101904.t002; https://dx.doi.org/10.1371/journal.pone.0101904.g007; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0101904.g007; https://dx.doi.org/10.1371/journal.pone.0101904.g005; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0101904.g005; https://dx.doi.org/10.1371/journal.pone.0101904.g001; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0101904.g001; http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0101904; https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0101904&type=printable; http://dx.plos.org/10.1371/journal.pone.0101904.g008; http://dx.plos.org/10.1371/journal.pone.0101904.g005; http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0101904; http://dx.plos.org/10.1371/journal.pone.0101904.g003; http://dx.plos.org/10.1371/journal.pone.0101904.g002; http://dx.plos.org/10.1371/journal.pone.0101904.g001; http://dx.plos.org/10.1371/journal.pone.0101904.g004; http://dx.plos.org/10.1371/journal.pone.0101904.t001; http://dx.plos.org/10.1371/journal.pone.0101904.g006; http://dx.plos.org/10.1371/journal.pone.0101904; http://www.plosone.org/article/metrics/info:doi/10.1371/journal.pone.0101904; http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0101904&type=printable; http://dx.plos.org/10.1371/journal.pone.0101904.t002; http://dx.plos.org/10.1371/journal.pone.0101904.g007
Public Library of Science (PLoS)
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know