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Maternal benzene exposure during pregnancy and risk of childhood acute lymphoblastic leukemia: A meta-analysis of epidemiologic studies

PLoS ONE, ISSN: 1932-6203, Vol: 9, Issue: 10, Page: e110466
2014
  • 60
    Citations
  • 0
    Usage
  • 109
    Captures
  • 2
    Mentions
  • 1
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    60
  • Captures
    109
  • Mentions
    2
    • Blog Mentions
      1
      • Blog
        1
    • News Mentions
      1
      • News
        1
  • Social Media
    1
    • Shares, Likes & Comments
      1
      • Facebook
        1

Most Recent News

Study: Benzene byproducts found in pregnant women near fracking sites

A Montreal study of exposure to high levels of benzene during pregnancy raises concerns about the risks for childhood leukemia. A team of Université de Montréal researchers looking at a small sample of 29 women living near major natural-gas well sites found high levels of toxins in their urine.   Researchers found they had 3.5 times more benzene byproducts in their urine than the average person in

Article Description

Background: The prevalence of childhood leukemia is increasing rapidly all over the world. However, studies on maternal benzene exposure during pregnancy and childhood acute lymphoblastic leukemia (ALL) have not been systematically assessed. Therefore, we performed a meta-analysis to investigate the association between maternal solvent, paint, petroleum exposure, and smoking during pregnancy and risk of childhood ALL. Methods: Relevant studies up to September 1, 2013 were identified by searching the PubMed, EMBASE, Cochrane library and the Web of Science databases. The effects were pooled using either fixed or random effect models based on the heterogeneity of the studies. Results: Twenty-eight case-control studies and one cohort study were included for analysis, with a total of 16,695 cases and 1,472,786 controls involved. Pooled odds ratio (OR) with 95% confidence interval (CI) for ALL was 1.25 (1.09, 1.45) for solvent, 1.23 (1.02, 1.47) for paint, 1.42 (1.10, 1.84) for petroleum exposure, and 0.99 (0.93, 1.06) for maternal smoking during pregnancy. No publication bias was found in this meta-analysis and consistent results were observed for subgroup and sensitivity analyses. Conclusions: Childhood ALL was associated with maternal solvent, paint, and petroleum exposure during pregnancy. No association was found between ALL and maternal smoking during pregnancy. Avoidance of maternal occupational and environmental benzene exposure during pregnancy could contribute to a decrease in the risk of childhood ALL.

Bibliographic Details

http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84908051709&origin=inward; http://dx.doi.org/10.1371/journal.pone.0110466; http://www.ncbi.nlm.nih.gov/pubmed/25333868; https://dx.plos.org/10.1371/journal.pone.0110466; https://dx.plos.org/10.1371/journal.pone.0110466.t002; http://dx.doi.org/10.1371/journal.pone.0110466.t002; https://dx.plos.org/10.1371/journal.pone.0110466.t003; http://dx.doi.org/10.1371/journal.pone.0110466.t003; https://dx.plos.org/10.1371/journal.pone.0110466.t001; http://dx.doi.org/10.1371/journal.pone.0110466.t001; https://dx.plos.org/10.1371/journal.pone.0110466.g003; http://dx.doi.org/10.1371/journal.pone.0110466.g003; https://dx.plos.org/10.1371/journal.pone.0110466.t004; http://dx.doi.org/10.1371/journal.pone.0110466.t004; https://dx.plos.org/10.1371/journal.pone.0110466.g004; http://dx.doi.org/10.1371/journal.pone.0110466.g004; https://dx.plos.org/10.1371/journal.pone.0110466.g001; http://dx.doi.org/10.1371/journal.pone.0110466.g001; https://dx.plos.org/10.1371/journal.pone.0110466.g002; http://dx.doi.org/10.1371/journal.pone.0110466.g002; https://dx.doi.org/10.1371/journal.pone.0110466.g001; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0110466.g001; https://dx.doi.org/10.1371/journal.pone.0110466.t001; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0110466.t001; https://dx.doi.org/10.1371/journal.pone.0110466.g002; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0110466.g002; https://dx.doi.org/10.1371/journal.pone.0110466.g003; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0110466.g003; https://dx.doi.org/10.1371/journal.pone.0110466.t002; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0110466.t002; https://dx.doi.org/10.1371/journal.pone.0110466.g004; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0110466.g004; https://dx.doi.org/10.1371/journal.pone.0110466.t004; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0110466.t004; https://dx.doi.org/10.1371/journal.pone.0110466; https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0110466; https://dx.doi.org/10.1371/journal.pone.0110466.t003; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0110466.t003; http://dx.plos.org/10.1371/journal.pone.0110466.g001; http://dx.plos.org/10.1371/journal.pone.0110466.t003; http://dx.plos.org/10.1371/journal.pone.0110466.t004; https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0110466&type=printable; http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0110466; http://www.plosone.org/article/metrics/info:doi/10.1371/journal.pone.0110466; http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0110466&type=printable; http://dx.plos.org/10.1371/journal.pone.0110466.t001; http://dx.plos.org/10.1371/journal.pone.0110466.g004; http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0110466; http://journals.plos.org/plosone/article/metrics?id=10.1371/journal.pone.0110466; http://dx.plos.org/10.1371/journal.pone.0110466.g003; http://dx.plos.org/10.1371/journal.pone.0110466.t002; http://dx.plos.org/10.1371/journal.pone.0110466; http://dx.plos.org/10.1371/journal.pone.0110466.g002

Yanfeng Zhou; Shaozun Zhang; Zhen Li; Jie Zhu; Yongyi Bi; YuE Bai; Hong Wang; Baohong Zhang

Public Library of Science (PLoS)

Multidisciplinary

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