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GB virus C (GBV-C) infection in hepatitis C virus (HCV) seropositive women with or at risk for HIV infection e114467

PLoS ONE, ISSN: 1932-6203, Vol: 9, Issue: 12, Page: e114467
2014
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Article Description

Results: 438 hepatitis C virus (HCV) seropositive women, including 306 HIVinfected and 132 HIV-uninfected women, from the HIV Epidemiologic Research Study were evaluated for GBV-C RNA. 347 (79.2%) women were GBV-C RNA negative, while 91 (20.8%) were GBV-C RNA positive. GBV-C positive women were younger than GBV-C negative women. Among 306 HIV-infected women, 70 (22.9%) women were HIV/GBV-C co-infected. Among HIV-infected women, the only significant difference between GBV-negative and GBV-positive women was age (mean 38.4 vs. 35.1 years; p<0.001). Median baseline CD4 cell counts and plasma HIV RNA levels were similar. The GBV-C genotypes were 1 (n531; 44.3%), 2 (n536; 51.4%), and 3 (n53; 4.3%). The distribution of GBV-C genotypes in coinfected women differed significantly by race/ethnicity. However, median CD4 cell counts and log10 HIV RNA levels did not differ by GBV-C genotype. GBV-C incidence was 2.7% over a median follow-up of 2.9 (IQR: 1.5, 4.9) years, while GBV-C clearance was 35.7% over a median follow-up of 2.44 (1.4, 3.5) years. 4 women switched genotypes. Background: GB virus C (GBV-C) may have a beneficial impact on HIV disease progression; however, the epidemiologic characteristics of this virus are not well characterized. Behavioral factors and gender may lead to differential rates of GBVC infection; yet, studies have rarely addressed GBV-C infections in women or racial/ethnic minorities. Therefore, we evaluated GBV-C RNA prevalence and genotype distribution in a large prospective study of high-risk women in the US. Conclusions: Age, injection drug use, a history of sex for money or drugs, and number of recent male sex partners were associated with GBV-C infection among all women in this analysis. However, CD4 cell count and HIV viral load of HIV/HCV/ GBV-C co-infected women were not different although race was associated with GBV-C genotype.

Bibliographic Details

http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84916624832&origin=inward; http://dx.doi.org/10.1371/journal.pone.0114467; http://www.ncbi.nlm.nih.gov/pubmed/25493916; https://facultyopinions.com/prime/725272622#eval793502518; http://dx.doi.org/10.3410/f.725272622.793502518; https://dx.plos.org/10.1371/journal.pone.0114467.t003; http://dx.doi.org/10.1371/journal.pone.0114467.t003; https://dx.plos.org/10.1371/journal.pone.0114467; https://dx.plos.org/10.1371/journal.pone.0114467.g001; http://dx.doi.org/10.1371/journal.pone.0114467.g001; https://dx.plos.org/10.1371/journal.pone.0114467.t002; http://dx.doi.org/10.1371/journal.pone.0114467.t002; https://dx.plos.org/10.1371/journal.pone.0114467.t001; http://dx.doi.org/10.1371/journal.pone.0114467.t001; https://dx.doi.org/10.1371/journal.pone.0114467.t003; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0114467.t003; https://dx.doi.org/10.1371/journal.pone.0114467.t002; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0114467.t002; https://dx.doi.org/10.1371/journal.pone.0114467; https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0114467; https://dx.doi.org/10.1371/journal.pone.0114467.g001; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0114467.g001; https://dx.doi.org/10.1371/journal.pone.0114467.t001; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0114467.t001; http://dx.plos.org/10.1371/journal.pone.0114467.t001; http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0114467; https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0114467&type=printable; http://dx.plos.org/10.1371/journal.pone.0114467.t003; http://www.plosone.org/article/metrics/info:doi/10.1371/journal.pone.0114467; http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0114467&type=printable; http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0114467; http://dx.plos.org/10.1371/journal.pone.0114467.t002; http://journals.plos.org/plosone/article/metrics?id=10.1371/journal.pone.0114467; http://dx.plos.org/10.1371/journal.pone.0114467; http://f1000.com/prime/725272622#eval793502518; http://dx.plos.org/10.1371/journal.pone.0114467.g001

Jason T. Blackard; Gang Ma; Jeffrey A. Welge; Caroline C. King; Lynn E. Taylor; Kenneth H. Mayer; Robert S. Klein; David D. Celentano; Jack D. Sobel; Denise J. Jamieson; Lytt Gardner; Claire Thorne

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