Plasma levels of microRNA-145 are associated with severity of coronary artery disease
PLoS ONE, ISSN: 1932-6203, Vol: 10, Issue: 5, Page: e0123477
2015
- 59Citations
- 62Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations59
- Citation Indexes59
- 59
- CrossRef14
- Captures62
- Readers62
- 62
Article Description
Background and Objective: MicroRNAs (miRNAs) have been shown to be associated with various physiological and pathological conditions, including inflammation and cardiovascular disease, but little is known about their relationship with the presence of coronary artery disease (CAD) and disease severity. Methods: A total of 195 consecutive subjects who underwent coronary angiography for chest pain evaluation were enrolled in this study. In CAD patients severity of coronary lesions was assessed by the number of diseased vessels and the Synergy between PCI with Taxus and Cardiac surgery score (SYNTAX score). Plasma levels of miRNA-145 were quantified by real-time quantitative polymerase chain reaction test, and logarithmic transformation of miRNA-145 levels (Ln-miRNA-145) was used for analyses due to its skewed distribution. Results: Of the 195 total subjects 167 patients were diagnosed as having CAD. Ln-miRNA-145 was significantly lower in CAD patients compared with the non-CAD group (-6.11±0.92 vs. -5.06 ±1.25; p<0.001). In multivariable linear regression analyses CAD was significantly associated with lower Ln-miRNA-145 (Estimate, -0.50; standard error (SE), 0.11; p <0.0001). Furthermore, among CAD patients, three-vessel disease, higher SYNTAX scores and STEMI were significantly associated with lower Ln-miRNA-145 ([Estimate,-0.40; SE, 0.07; p <0.0001]; [Estimate, -0.02, SE, 0.10; p = 0.005] and [Estimate, -0.35, SE, 0.10; p <0.001] respectively). Conclusions: Lower plasma levels of miRNA-145 were significantly associated with the presence as well as severity of CAD. As a potential biomarker for CAD, plasma miRNA-145 may be useful in predicting CAD and its severity in patients presenting with chest pain.
Bibliographic Details
10.1371/journal.pone.0123477; 10.1371/journal.pone.0123477.t002; 10.1371/journal.pone.0123477.g003; 10.1371/journal.pone.0123477.t001; 10.1371/journal.pone.0123477.g001; 10.1371/journal.pone.0123477.g004; 10.1371/journal.pone.0123477.t003; 10.1371/journal.pone.0123477.g002
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84929090912&origin=inward; http://dx.doi.org/10.1371/journal.pone.0123477; http://www.ncbi.nlm.nih.gov/pubmed/25938589; https://dx.plos.org/10.1371/journal.pone.0123477.t002; http://dx.doi.org/10.1371/journal.pone.0123477.t002; https://dx.plos.org/10.1371/journal.pone.0123477.g003; http://dx.doi.org/10.1371/journal.pone.0123477.g003; https://dx.plos.org/10.1371/journal.pone.0123477.t001; http://dx.doi.org/10.1371/journal.pone.0123477.t001; https://dx.plos.org/10.1371/journal.pone.0123477; https://dx.plos.org/10.1371/journal.pone.0123477.g001; http://dx.doi.org/10.1371/journal.pone.0123477.g001; https://dx.plos.org/10.1371/journal.pone.0123477.g004; http://dx.doi.org/10.1371/journal.pone.0123477.g004; https://dx.plos.org/10.1371/journal.pone.0123477.t003; http://dx.doi.org/10.1371/journal.pone.0123477.t003; https://dx.plos.org/10.1371/journal.pone.0123477.g002; http://dx.doi.org/10.1371/journal.pone.0123477.g002; https://dx.doi.org/10.1371/journal.pone.0123477.t002; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0123477.t002; https://dx.doi.org/10.1371/journal.pone.0123477.g004; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0123477.g004; https://dx.doi.org/10.1371/journal.pone.0123477; https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0123477; https://dx.doi.org/10.1371/journal.pone.0123477.g001; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0123477.g001; https://dx.doi.org/10.1371/journal.pone.0123477.t001; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0123477.t001; https://dx.doi.org/10.1371/journal.pone.0123477.g003; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0123477.g003; https://dx.doi.org/10.1371/journal.pone.0123477.t003; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0123477.t003; https://dx.doi.org/10.1371/journal.pone.0123477.g002; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0123477.g002; http://dx.plos.org/10.1371/journal.pone.0123477.g001; http://dx.plos.org/10.1371/journal.pone.0123477.g003; http://dx.plos.org/10.1371/journal.pone.0123477.t001; http://dx.plos.org/10.1371/journal.pone.0123477.g002; http://journals.plos.org/plosone/article/metrics?id=10.1371/journal.pone.0123477; https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0123477&type=printable; http://dx.plos.org/10.1371/journal.pone.0123477.t003; http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0123477; http://dx.plos.org/10.1371/journal.pone.0123477.t002; http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0123477; http://dx.plos.org/10.1371/journal.pone.0123477; http://dx.plos.org/10.1371/journal.pone.0123477.g004; http://www.plosone.org/article/metrics/info:doi/10.1371/journal.pone.0123477; http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0123477&type=printable
Public Library of Science (PLoS)
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know