HIV-1 dual infected LTNP-EC patients developed an unexpected antibody cross-neutralizing activity
PLoS ONE, ISSN: 1932-6203, Vol: 10, Issue: 8, Page: e0134054
2015
- 5Citations
- 18Captures
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Metrics Details
- Citations5
- Citation Indexes5
- CrossRef2
- Captures18
- Readers18
- 18
Article Description
This study evaluated the neutralization breadth in dually infected (DI) HIV-1 long-term nonprogressor elite controller patients (LTNP-EC) using a representative minipanel of 6 viruses from 5 different subtypes. Our results showed an improved neutralization breadth in DI LTNP-EC patients when compared with matched LTNP single-infected patients. The role of viral diversity in neutralization was estimated with the Shannon Entropy and the p-distance in viral quasispecies. We found a positive correlation between neutralization breadth and diversity within the viral quasispecies. This correlation could explain why a group of LTNP-EC patients developed a broad neutralizing response despite having undetectable levels of viremia. Copyright:
Bibliographic Details
10.1371/journal.pone.0134054; 10.1371/journal.pone.0134054.t001; 10.1371/journal.pone.0134054.g003; 10.1371/journal.pone.0134054.g001; 10.1371/journal.pone.0134054.g002
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