Telomere length in peripheral blood leukocytes is associated with severity of biliary atresia
PLoS ONE, ISSN: 1932-6203, Vol: 10, Issue: 7, Page: e0134689
2015
- 17Citations
- 17Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations17
- Citation Indexes17
- 17
- CrossRef11
- Captures17
- Readers17
- 17
Article Description
Objective The purpose of this study was to investigate the association of telomere length in peripheral blood leukocytes with the severity of biliary atresia (BA). Methods One hundred and fourteen BA patients and 114 age-matched healthy controls were enrolled. Relative telomere length (RTL) was assessed using a quantitative real-time polymerase chain reaction. Multivariate regression analysis was used to estimate RTL as an independent risk factor of BA. Receiver operating characteristic curve analysis was used to calculate the accuracy of biomarkers in the prediction of liver cirrhosis. Results BA patients had significantly shorter telomeres than healthy controls (p < 0.0001). The RTL in BA patients with jaundice was considerably lower than that of patients without jaundice (p = 0.005). Moreover, RTL was markedly shorter in patients with cirrhosis (F4), as compared to patients with mild fibrosis (F2) and non-fibrosis (F0-F1, p < 0.0001). Logistic regression analysis indicated that short RTL was associated with a higher risk of liver cirrhosis in BA. Tertile analysis showed a dose-response effect for this association (p trend < 0.0001). Additionally, RTL in BA children revealed a negative correlation with age (r =-0.50, p < 0.001).We noted an association between reduction of RTL and liver stiffness scores, adjusted for age and gender (b =-0.01, p < 0.0001). Short RTL can be employed to distinguish cirrhosis patients from non-cirrhosis patients (AUC = 0.78). Further analysis showed a linear correlation between leukocyte RTL and liver RTL in BA patients (r = 0.83, p < 0.001). Conclusion The findings of this study provide evidence that telomere shortening is associated with an elevated risk of iver cirrhosis in BA.
Bibliographic Details
10.1371/journal.pone.0134689; 10.1371/journal.pone.0134689.g005; 10.1371/journal.pone.0134689.g002; 10.1371/journal.pone.0134689.g001; 10.1371/journal.pone.0134689.g004; 10.1371/journal.pone.0134689.g003; 10.1371/journal.pone.0134689.t001
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84941978928&origin=inward; http://dx.doi.org/10.1371/journal.pone.0134689; http://www.ncbi.nlm.nih.gov/pubmed/26230851; https://dx.plos.org/10.1371/journal.pone.0134689.g005; http://dx.doi.org/10.1371/journal.pone.0134689.g005; https://dx.plos.org/10.1371/journal.pone.0134689.g002; http://dx.doi.org/10.1371/journal.pone.0134689.g002; https://dx.plos.org/10.1371/journal.pone.0134689.g001; http://dx.doi.org/10.1371/journal.pone.0134689.g001; https://dx.plos.org/10.1371/journal.pone.0134689.g004; http://dx.doi.org/10.1371/journal.pone.0134689.g004; https://dx.plos.org/10.1371/journal.pone.0134689.g003; http://dx.doi.org/10.1371/journal.pone.0134689.g003; https://dx.plos.org/10.1371/journal.pone.0134689.t001; http://dx.doi.org/10.1371/journal.pone.0134689.t001; https://dx.plos.org/10.1371/journal.pone.0134689; https://dx.doi.org/10.1371/journal.pone.0134689.g004; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0134689.g004; https://dx.doi.org/10.1371/journal.pone.0134689.t001; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0134689.t001; https://dx.doi.org/10.1371/journal.pone.0134689.g003; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0134689.g003; https://dx.doi.org/10.1371/journal.pone.0134689.g002; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0134689.g002; https://dx.doi.org/10.1371/journal.pone.0134689; https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0134689; https://dx.doi.org/10.1371/journal.pone.0134689.g001; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0134689.g001; https://dx.doi.org/10.1371/journal.pone.0134689.g005; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0134689.g005; http://dx.plos.org/10.1371/journal.pone.0134689.t001; https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0134689&type=printable; http://dx.plos.org/10.1371/journal.pone.0134689.g003; http://journals.plos.org/plosone/article/metrics?id=10.1371/journal.pone.0134689; http://dx.plos.org/10.1371/journal.pone.0134689; http://dx.plos.org/10.1371/journal.pone.0134689.g005; http://dx.plos.org/10.1371/journal.pone.0134689.g002; http://www.plosone.org/article/metrics/info:doi/10.1371/journal.pone.0134689; http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0134689&type=printable; http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0134689; http://dx.plos.org/10.1371/journal.pone.0134689.g001; http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0134689; http://dx.plos.org/10.1371/journal.pone.0134689.g004
Public Library of Science (PLoS)
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know