Angiopoietin-like-4, a potential target of tacrolimus, predicts earlier podocyte injury in minimal change disease
PLoS ONE, ISSN: 1932-6203, Vol: 10, Issue: 9, Page: e0137049
2015
- 25Citations
- 22Captures
- 1Mentions
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations25
- Citation Indexes25
- 25
- CrossRef7
- Captures22
- Readers22
- 22
- Mentions1
- News Mentions1
- News1
Most Recent News
Serum and urine ANGPTL8 expression levels are associated with hyperlipidemia and proteinuria in primary nephrotic syndrome
This study aimed to investigate the expression characteristics of ANGPTL8 in patients with primary nephrotic syndrome and its possible correlation with hyperlipidemia and proteinuria. Methods
Article Description
Podocyte injury plays central roles in proteinuria and kidney dysfunction, therefore, identifying specific biomarker to evaluate earlier podocyte injury is highly desirable. Podocytesecreted angiopoietin-like-4 (Angptl4) mediates proteinuria in different types of podocytopathy. In the present study, we established an experimental minimal change disease (MCD) rat model, induced by adriamycin (ADR) and resulted in definite podocyte injury, to identify the dynamic changes in Angptl4 expression. We also investigated the direct effects of tacrolimus on Angptl4 and podocyte repair. We determined that the glomerular Angptl4 expression was rapidly upregulated and reached a peak earlier than desmin, an injured podocyte marker, in the ADR rats. Furthermore, this upregulation occurred prior to heavy proteinuria and was accompanied by increased urinary Angptl4.We observed that the Angptl4 upregulation occurred only when podocyte was mainly damaged since we didn't observe little Angptl4 upregulation in MsPGN patients. In addition, we observed the glomerular Angptl4 mainly located in injured podocytes rather than normal podocytes. Moreover, we found that tacrolimus treatment significantly promoted podocyte repair and reduced glomerular and urinary Angptl4 expression at an earlier stage with a significant serum Angptl4 upregulation. And similar results were confirmed in MCD patients. In conclusion, this study represents the first investigation to demonstrate that Angptl4 can predict podocyte injury at earlier stages in MCD and the identification of earlier podocyte injury biomarkers could facilitate the prompt diagnosis and treatment of patients with podocytopathy, as well as determination of the prognosis and treatment efficacy in these diseases. Copyright:
Bibliographic Details
10.1371/journal.pone.0137049; 10.1371/journal.pone.0137049.g001; 10.1371/journal.pone.0137049.g003; 10.1371/journal.pone.0137049.g002; 10.1371/journal.pone.0137049.t001; 10.1371/journal.pone.0137049.g004; 10.1371/journal.pone.0137049.g005
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84944735709&origin=inward; http://dx.doi.org/10.1371/journal.pone.0137049; http://www.ncbi.nlm.nih.gov/pubmed/26352670; https://dx.plos.org/10.1371/journal.pone.0137049.g001; http://dx.doi.org/10.1371/journal.pone.0137049.g001; https://dx.plos.org/10.1371/journal.pone.0137049.g003; http://dx.doi.org/10.1371/journal.pone.0137049.g003; https://dx.plos.org/10.1371/journal.pone.0137049.g002; http://dx.doi.org/10.1371/journal.pone.0137049.g002; https://dx.plos.org/10.1371/journal.pone.0137049.t001; http://dx.doi.org/10.1371/journal.pone.0137049.t001; https://dx.plos.org/10.1371/journal.pone.0137049.g004; http://dx.doi.org/10.1371/journal.pone.0137049.g004; https://dx.plos.org/10.1371/journal.pone.0137049.g005; http://dx.doi.org/10.1371/journal.pone.0137049.g005; https://dx.plos.org/10.1371/journal.pone.0137049; https://dx.doi.org/10.1371/journal.pone.0137049.g004; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0137049.g004; https://dx.doi.org/10.1371/journal.pone.0137049.t001; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0137049.t001; https://dx.doi.org/10.1371/journal.pone.0137049.g003; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0137049.g003; https://dx.doi.org/10.1371/journal.pone.0137049; https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0137049; https://dx.doi.org/10.1371/journal.pone.0137049.g002; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0137049.g002; https://dx.doi.org/10.1371/journal.pone.0137049.g001; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0137049.g001; https://dx.doi.org/10.1371/journal.pone.0137049.g005; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0137049.g005; http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0137049; https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0137049&type=printable; http://journals.plos.org/plosone/article/metrics?id=10.1371/journal.pone.0137049; http://dx.plos.org/10.1371/journal.pone.0137049.g004; http://www.plosone.org/article/metrics/info:doi/10.1371/journal.pone.0137049; http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0137049&type=printable; http://dx.plos.org/10.1371/journal.pone.0137049.g001; http://dx.plos.org/10.1371/journal.pone.0137049; http://dx.plos.org/10.1371/journal.pone.0137049.t001; http://dx.plos.org/10.1371/journal.pone.0137049.g002; http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0137049; http://dx.plos.org/10.1371/journal.pone.0137049.g003; http://dx.plos.org/10.1371/journal.pone.0137049.g005
Public Library of Science (PLoS)
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know