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Effects of statin therapy on clinical outcomes of survivors of acute myocardial infarction with severe systolic heart failure

PLoS ONE, ISSN: 1932-6203, Vol: 10, Issue: 12, Page: e0144602
2015
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Article Description

Objective Large randomized trials have failed to show a beneficial effect of statin treatment in chronic HF. The investigators tried to evaluate the long-term effects of statin therapy in patients with new onset heart failure (HF) following acute myocardial infarction (AMI). Methods Between January 2008 and December 2011, a total of 13,616 AMI patients were enrolled in the Korea Acute Myocardial Infarction Registry (KAMIR) which was a prospective, multicenter, nationwide, web-based database of AMI in Korea. From this database, we studied 1,055 patients with AMI who had newly developed severe acute HF [left ventricular ejection fraction 40%] and were discharged alive. The patients were divided into two groups, a statin group (n = 756) and a no-statin group (n = 299).We investigated the one-year major adverse cardiovascular events (MACEs), including all-cause mortality, MI, and any revascularization of each group. We then performed a propensity-score matched analysis. Results In the original cohort, one-year MACEs were similar between the two groups (16.5% vs. 14.7% in the statin or no-statin groups; p = 0.47). Propensity-score matching yielded 256 pairs, and in that population we observed comparable results in terms of MACEs (18.0% vs. 12.5% in the statin or no-statin groups, p = 0.11) and mortality (5.1% vs. 3.5% in the statin or no-statin groups, p = 0.51). Cox-regression analysis revealed that statin therapy was not an independent predictor for occurrence of a MACE [Hazard ratio (HR) 1.11, 95% CI 0.79â€" 1.57, p = 0.54] or all-cause mortality (HR 1.42, 95% CI 0.75â€"2.70, p = 0.28). Conclusion Statin therapy was not associated with a reduction in the long-term occurrence of MACEs or mortality in survivors of AMI with severe acute HF in this retrospective cohort study.

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http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84961375033&origin=inward; http://dx.doi.org/10.1371/journal.pone.0144602; http://www.ncbi.nlm.nih.gov/pubmed/26658751; https://dx.plos.org/10.1371/journal.pone.0144602; https://dx.plos.org/10.1371/journal.pone.0144602.g002; http://dx.doi.org/10.1371/journal.pone.0144602.g002; https://dx.plos.org/10.1371/journal.pone.0144602.g001; http://dx.doi.org/10.1371/journal.pone.0144602.g001; https://dx.doi.org/10.1371/journal.pone.0144602; https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0144602; https://dx.doi.org/10.1371/journal.pone.0144602.g002; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0144602.g002; https://dx.doi.org/10.1371/journal.pone.0144602.g001; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0144602.g001; http://dx.plos.org/10.1371/journal.pone.0144602.g002; https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0144602&type=printable; http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0144602; http://dx.plos.org/10.1371/journal.pone.0144602; http://dx.plos.org/10.1371/journal.pone.0144602.g001; http://www.plosone.org/article/metrics/info:doi/10.1371/journal.pone.0144602; http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0144602&type=printable; http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0144602; http://journals.plos.org/plosone/article/metrics?id=10.1371/journal.pone.0144602

Jong Shin Woo; Seung Joon Hwang; Hyun Soo Kim; Jin Bae Kim; Woo Shik Kim; Kwon Sam Kim; Weon Kim; Myung Ho Jeong; Young Keun Ahn; Sung Chull Chae; Jong Hyun Kim; Seung Ho Hur; Young Jo Kim; In Whan Seong; Dong Hoon Choi; Jei Keon Chae; Taek Jong Hong; Jae Young Rhew; Doo Il Kim; In Ho Chae; Jung Han Yoon; Bon Kwon Koo; Byung Ok Kim; Myoung Yong Lee; Kee Sik Kim; Jin Yong Hwang; Myeong Chan Cho; Seok Kyu Oh; Nae Hee Lee; Seung Jea Tahk; Jang Ho Bae; Seung Woon Rha; Keum Soo Park; Chong Jin Kim; Kyoo Rok Han; Tae Hoon Ahn; Moo Hyun Kim; Ki Bae Seung; Wook Sung Chung; Ju Young Yang; Chong Yun Rhim; Hyeon Cheol Gwon; Seong Wook Park; Young Youp Koh; Seung Jae Joo; Soo Joong Kim; Dong Kyu Jin; Jin Man Cho; Sang Wook Kim; Jeong Kyung Kim; Tae Ik Kim; Deug Young Nah; Si Hoon Park; Sang Hyun Lee; Seung Uk Lee; Hang Jae Chung; Jang Hyun Cho; Seung Won Jin; Yang Soo Jang; Jeong Gwan Cho; Seung Jung Park

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