Effects of statin therapy on clinical outcomes of survivors of acute myocardial infarction with severe systolic heart failure
PLoS ONE, ISSN: 1932-6203, Vol: 10, Issue: 12, Page: e0144602
2015
- 4Citations
- 38Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations4
- Citation Indexes4
- CrossRef1
- Captures38
- Readers38
- 38
Article Description
Objective Large randomized trials have failed to show a beneficial effect of statin treatment in chronic HF. The investigators tried to evaluate the long-term effects of statin therapy in patients with new onset heart failure (HF) following acute myocardial infarction (AMI). Methods Between January 2008 and December 2011, a total of 13,616 AMI patients were enrolled in the Korea Acute Myocardial Infarction Registry (KAMIR) which was a prospective, multicenter, nationwide, web-based database of AMI in Korea. From this database, we studied 1,055 patients with AMI who had newly developed severe acute HF [left ventricular ejection fraction 40%] and were discharged alive. The patients were divided into two groups, a statin group (n = 756) and a no-statin group (n = 299).We investigated the one-year major adverse cardiovascular events (MACEs), including all-cause mortality, MI, and any revascularization of each group. We then performed a propensity-score matched analysis. Results In the original cohort, one-year MACEs were similar between the two groups (16.5% vs. 14.7% in the statin or no-statin groups; p = 0.47). Propensity-score matching yielded 256 pairs, and in that population we observed comparable results in terms of MACEs (18.0% vs. 12.5% in the statin or no-statin groups, p = 0.11) and mortality (5.1% vs. 3.5% in the statin or no-statin groups, p = 0.51). Cox-regression analysis revealed that statin therapy was not an independent predictor for occurrence of a MACE [Hazard ratio (HR) 1.11, 95% CI 0.79â€" 1.57, p = 0.54] or all-cause mortality (HR 1.42, 95% CI 0.75â€"2.70, p = 0.28). Conclusion Statin therapy was not associated with a reduction in the long-term occurrence of MACEs or mortality in survivors of AMI with severe acute HF in this retrospective cohort study.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84961375033&origin=inward; http://dx.doi.org/10.1371/journal.pone.0144602; http://www.ncbi.nlm.nih.gov/pubmed/26658751; https://dx.plos.org/10.1371/journal.pone.0144602; https://dx.plos.org/10.1371/journal.pone.0144602.g002; http://dx.doi.org/10.1371/journal.pone.0144602.g002; https://dx.plos.org/10.1371/journal.pone.0144602.g001; http://dx.doi.org/10.1371/journal.pone.0144602.g001; https://dx.doi.org/10.1371/journal.pone.0144602; https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0144602; https://dx.doi.org/10.1371/journal.pone.0144602.g002; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0144602.g002; https://dx.doi.org/10.1371/journal.pone.0144602.g001; https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0144602.g001; http://dx.plos.org/10.1371/journal.pone.0144602.g002; https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0144602&type=printable; http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0144602; http://dx.plos.org/10.1371/journal.pone.0144602; http://dx.plos.org/10.1371/journal.pone.0144602.g001; http://www.plosone.org/article/metrics/info:doi/10.1371/journal.pone.0144602; http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0144602&type=printable; http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0144602; http://journals.plos.org/plosone/article/metrics?id=10.1371/journal.pone.0144602
Public Library of Science (PLoS)
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know