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The features of inflammation factors concentrations in aqueous humor of polypoidal choroidal vasculopathy

PLoS ONE, ISSN: 1932-6203, Vol: 11, Issue: 1, Page: e0147346
2016
  • 13
    Citations
  • 0
    Usage
  • 22
    Captures
  • 1
    Mentions
  • 1
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    13
  • Captures
    22
  • Mentions
    1
    • News Mentions
      1
      • 1
  • Social Media
    1
    • Shares, Likes & Comments
      1
      • Facebook
        1

Most Recent News

Intraocular Cytokine in Recurrence of Polypoidal Choroidal Vasculopathy; CyPov

STUDY INFORMATION OFFICIAL TITLE: Intraocular Cytokine Changes in Recurrence of Polypoidal Choroidal Vasculopathy CURRENT STATUS: Not yet recruiting STUDY TYPE: Interventional SPONSOR AGENCY:Pusan National University

Article Description

Purpose To investigate the cytokine concentrations in the aqueous humor of patients with refractory polypoidal choroidal vasculopathy (PCV). Methods Three separate groups of patients were studied refractory PCV (Group A, 41 eyes), stable PCV (Group B, 39 eyes) and senile cataract (Group C, 44 eyes). Aqueous humor samples were collected at two time points for Groups A and B before the first intravitreal ranibizumab injection and before the last injection. Aqueous humor samples were collected prior to phacoemulsification in Group C. The cytokine concentrations of interleukin 2, 6, and 8 (IL-2, IL-6, and IL-8), tumor necrosis factor α (TNF-α), monocyte chemotactic protein 1 (MCP-1), and vascular endothelial growth factor (VEGF) were measured by cytometric bead array and flow cytometry. Results Before the first treatment, the MCP-1, VEGF, and TNF-α levels in Group A were significantly higher than those in Group C (P < 0.05), and the MCP-1 and VEGF levels in Group A were significantly higher than those in Group B (P < 0.05). Significantly higher MCP-1 and VEGF levels were seen in Group B compared to Group C (P < 0.05). Before the final treatment, the MCP-1, VEGF, and TNF-α concentrations in Group A were significantly higher than those in Group B (P < 0.05) and Group C (P < 0.05). IL-2 levels were significantly lower in Group A compared to Group B (P < 0.05) and Group C (P < 0.05). Conclusion Inflammatory cytokines such as MCP-1, VEGF, and TNF-α may be associated with the pathogenesis of both stable and refractory PCV.

Bibliographic Details

Jie Hu; Xuan Leng; Yijun Hu; Alp Atik; Xin Song; Zhixi Li; Yuhua Liu; Lin Lu; Demetrios G. Vavvas

Public Library of Science (PLoS)

Biochemistry, Genetics and Molecular Biology; Agricultural and Biological Sciences; Multidisciplinary

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