Striatal astrocytes engulf dopaminergic debris in Parkinson’s disease: A study in an animal model
PLoS ONE, ISSN: 1932-6203, Vol: 12, Issue: 10, Page: e0185989
2017
- 36Citations
- 73Captures
- 1Mentions
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Metrics Details
- Citations36
- Citation Indexes36
- 36
- CrossRef2
- Captures73
- Readers73
- 73
- Mentions1
- News Mentions1
- News1
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Striatal astrocytes engulf dopaminergic debris in Parkinson's disease: A study in an animal model.
PLoS One. 2017;12(10):e0185989. Epub 2017 Oct 13 Authors: Morales I, Sanchez A, Rodriguez-Sabate C, Rodriguez M PubMed: 29028815 Submit Comment
Article Description
The role of astrocytes in Parkinson’s disease is still not well understood. This work studied the astrocytic response to the dopaminergic denervation. Rats were injected in the lateral ventricles with 6-hydroxydopamine (25μg), inducing a dopaminergic denervation of the striatum not accompanied by non-selective tissue damage. The dopaminergic debris were found within spheroids (free-spheroids) which retained some proteins of dopaminergic neurons (e.g., tyrosine hydroxylase, the dopamine transporter protein, and APP) but not others (e.g., α-synuclein). Free-spheroids showed the initial (LC3-autophagosomes) but not the late (Lamp1/Lamp2-lysosomes) components of autophagy (incomplete autophagy), preparing their autophagosomes for an external phagocytosis (accumulation of phosphatidylserine). Free-spheroids were penetrated by astrocyte processes (fenestrated-spheroids) which made them immunoreactive for GFAP and S100β, and which had some elements needed to continue the debris degradation (Lamp1/Lamp2). Finally, proteins normally found in neurons (TH, DAT and α-synuclein) were observed within astrocytes 2–5 days after the dopaminergic degeneration, suggesting that the intracellular contents of degenerated cells had been transferred to astrocytes. Taken together, present data suggest phagocytosis as a physiological role of striatal astrocytes, a role which could be critical for cleaning striatal debris during the initial stages of Parkinson’s disease.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85031295502&origin=inward; http://dx.doi.org/10.1371/journal.pone.0185989; http://www.ncbi.nlm.nih.gov/pubmed/29028815; https://dx.plos.org/10.1371/journal.pone.0185989; https://dx.doi.org/10.1371/journal.pone.0185989; https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0185989
Public Library of Science (PLoS)
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