Longer TOMM40 poly-T variants associated with higher FDDNP-PET medial temporal tau and amyloid binding
PLoS ONE, ISSN: 1932-6203, Vol: 13, Issue: 12, Page: e0208358
2018
- 8Citations
- 38Captures
- 1Mentions
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Metrics Details
- Citations8
- Citation Indexes8
- CrossRef1
- Captures38
- Readers38
- 38
- Mentions1
- News Mentions1
- News1
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Longer TOMM40 poly-T variants associated with higher FDDNP-PET medial temporal tau and amyloid binding.
PLoS One. 2018;13(12):e0208358. Epub 2018 Dec 5 Authors: Siddarth P, Burggren AC, Merrill DA, Ercoli LM, Mahmood Z, Barrio JR, Small GW PubMed: 30517207 Submit Comment
Article Description
The translocase of outer mitochondrial membrane 40 (TOMM40), which lies in linkage disequilibrium with the apolipoprotein E (APOE) gene, has been implicated in Alzheimer’s disease (AD). TOMM40 influences AD pathology through mitochondrial neurotoxicity, and the medial temporal lobe (MTL) is the most likely brain region for identifying early manifestations of AD-related morphology changes. While early reports indicated that the longer length poly-T allele of TOMM40 increases risk for AD, these findings have not been consistently replicated in further studies. We examined the effect of TOMM40 and APOE on regional brain positron emission tomography (PET) 2-(1-{6-[(2 [F18]fluoroethyl) (methyl) amino]-2-naphthyl}ethylidene)malononitrile (FDDNP) binding values in MTL.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85057956318&origin=inward; http://dx.doi.org/10.1371/journal.pone.0208358; http://www.ncbi.nlm.nih.gov/pubmed/30517207; https://dx.plos.org/10.1371/journal.pone.0208358; https://dx.doi.org/10.1371/journal.pone.0208358; https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208358
Public Library of Science (PLoS)
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