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Thermoresponsive polymer surfaces and their application in tissue engineering

Polimery/Polymers, ISSN: 0032-2725, Vol: 63, Issue: 5, Page: 327-338
2018
  • 13
    Citations
  • 0
    Usage
  • 18
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    13
    • Citation Indexes
      13
  • Captures
    18

Review Description

This short review addresses the synthesis of thermoresponsive polymer surfaces and their application for cell tissue engineering. Four classes of synthetic thermoresponsive polymers are discussed: poly(N-isopropylacrylamide)s, poly[oligo(ethylene glycol) methacrylate]s, polyoxazolines and polyethers, most notably, polyglycidol. Synthetic routes leading to thermoresponsive layers on solid support are described. Relationships between structures of the layers and their interactions with cells are analyzed. Chemical (copolymerization or the inclusion of biologically active species) and physical (patterning or the morphology of the surfaces) modifications of macromolecular surfaces are described and their relations to the growth and detachment of cell sheets are reviewed. The application of cell sheets grown and detached from thermoresponsive surfaces to treat diseases is also presented.

Bibliographic Details

Alicja Utrata-Wesolek; Natalia Oleszko-Torbus; Marcelina Bochenek; Dominik Kosowski; Agnieszka Kowalczuk; Barbara Trzebicka; Andrzej Dworak

LUKASIEWICZ Research Network - Industrial Chemistry Research Institute

Chemical Engineering; Materials Science

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