Influence of nicotinamide administration on the bile-acid pattern in rats given streptozotocin
Biological Chemistry Hoppe-Seyler, ISSN: 1437-4315, Vol: 371, Issue: 2, Page: 637-640
1990
- 1Citations
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Metrics Details
- Citations1
- Citation Indexes1
Article Description
Diese Untersuchung wurde durchgeführt, um die Möglichkeit auszuschließen, daß Streptozotocin (STZ) als solches unmittelbar für die Veränderung im Stoffwechsel der Gallensäuren verantwortlich sein kann. Verglichen mit der Kontrolle, enthielt die Gallenflüssigkeit STZ-diabetischer Ratten einen höheren Cholsäureanteil und weniger Chenodesoxycholsäure und β-Muricholsäure. Trotz Behandlung der Ratten mit STZ blieb die Veränderung des Gallensäurenmusters dann aus, wenn durch gleichzeitige Nicotinamidgabe das Auftreten des Diabetes verhindert wurde. Nicotinamid selbst hatte keinen Einfluß auf die Zusammensetzung der Gallensäuren. Behandlung STZ-diabetischer Ratten mit Insulin hob das veränderte Gallensäurenmuster teilweise auf. Aus den Ergebnissen folgt, daß die Veränderung im Stoffwechsel der Gallensäuren bei den STZ-behandelten Ratten nicht eine unmittelbare Wirkung des STZ selbst ist, sondern durch einen STZ-induzierten, absoluten oder relativen Mangelzustand an Insulin hervorgerufen wird. © 1990 Walter de Gruyter. Alle Rechte vorbehalten
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0024989521&origin=inward; http://dx.doi.org/10.1515/bchm3.1990.371.2.637; https://www.degruyter.com/document/doi/10.1515/bchm3.1990.371.2.637/html; https://www.degruyter.com/document/doi/10.1515/bchm3.1990.371.2.637/pdf; https://www.degruyter.com/view/j/bchm3.1990.371.issue-2/bchm3.1990.371.2.637/bchm3.1990.371.2.637.xml
Walter de Gruyter GmbH
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