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Endocytosis by Liver Cells During Suppression of Intralysosomal Proteolysis

Biological Chemistry Hoppe-Seyler, ISSN: 1437-4315, Vol: 373, Issue: 2, Page: 573-580
1992
  • 20
    Citations
  • 0
    Usage
  • 4
    Captures
  • 0
    Mentions
  • 5,845
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    20
  • Captures
    4
  • Social Media
    5,845
    • Shares, Likes & Comments
      5,845
      • Facebook
        5,845

Article Description

The lysosomotropic agent chloroquine is widely used as a specific inhibitor of intralysosomal proteolysis in isolated hepatocytes. It was shown that in vitro chloroquine reversibly inhibited purified cathepsins H, B, L in concentrations less than those observed inside lysosomes in vivo. However, administration of high doses of chloroquine to rats (30 - 50 mg/kg i.p. as a single or repeated injections) was followed by increased cathepsin D and cysteine proteinase activities, as well as other lysosomal enzymes. Chloroquine administration did not induce any changes of carbon particles phagocytosis by liver cells (macrophages); modifications of fluid-phase (125I-PVP uptake) and receptor-mediated endocytosis (125I-asialo-fetuin uptake) were noted. Chloroquine administered in vivo reproduced some symptoms of lysosomal storage diseases (especially during repeated drug administration). © 1992, Walter de Gruyter. All rights reserved.

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