Endocytosis by Liver Cells During Suppression of Intralysosomal Proteolysis
Biological Chemistry Hoppe-Seyler, ISSN: 1437-4315, Vol: 373, Issue: 2, Page: 573-580
1992
- 20Citations
- 4Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations20
- Citation Indexes20
- 20
- CrossRef11
- Captures4
- Readers4
Article Description
The lysosomotropic agent chloroquine is widely used as a specific inhibitor of intralysosomal proteolysis in isolated hepatocytes. It was shown that in vitro chloroquine reversibly inhibited purified cathepsins H, B, L in concentrations less than those observed inside lysosomes in vivo. However, administration of high doses of chloroquine to rats (30 - 50 mg/kg i.p. as a single or repeated injections) was followed by increased cathepsin D and cysteine proteinase activities, as well as other lysosomal enzymes. Chloroquine administration did not induce any changes of carbon particles phagocytosis by liver cells (macrophages); modifications of fluid-phase (125I-PVP uptake) and receptor-mediated endocytosis (125I-asialo-fetuin uptake) were noted. Chloroquine administered in vivo reproduced some symptoms of lysosomal storage diseases (especially during repeated drug administration). © 1992, Walter de Gruyter. All rights reserved.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0026890910&origin=inward; http://dx.doi.org/10.1515/bchm3.1992.373.2.573; http://www.ncbi.nlm.nih.gov/pubmed/1515086; https://www.degruyter.com/document/doi/10.1515/bchm3.1992.373.2.573/html; https://www.degruyter.com/view/j/bchm3.1992.373.issue-2/bchm3.1992.373.2.573/bchm3.1992.373.2.573.xml
Walter de Gruyter GmbH
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