Characteristics of antibiotic resistance mechanisms and genes of Klebsiella pneumoniae
Open Medicine (Poland), ISSN: 2391-5463, Vol: 18, Issue: 1, Page: 20230707
2023
- 23Citations
- 265Captures
- 3Mentions
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Metrics Details
- Citations23
- Citation Indexes23
- 23
- Captures265
- Readers265
- 265
- Mentions3
- News Mentions2
- News2
- References1
- Wikipedia1
Most Recent News
Mechanisms of Antibiotic Resistance and Developments in Therapeutic Strategies to Combat Klebsiella pneumoniae Infection
Introduction Klebsiella pneumoniae (K. pneumoniae) is a gram-negative bacterium found primarily in the respiratory tract and intestines of humans, often causes nosocomial infections, leading to
Review Description
Klebsiella pneumoniae is an important multidrug-resistant (MDR) pathogen that can cause a range of infections in hospitalized patients. With the growing use of antibiotics, MDR K. pneumoniae is more prevalent, posing additional difficulties and obstacles in clinical therapy. To provide a valuable reference to deeply understand K. pneumoniae, and also to provide the theoretical basis for clinical prevention of such bacteria infections, the antibiotic resistance and mechanism of K. pneumoniae are discussed in this article. We conducted a literature review on antibiotic resistance of K. pneumoniae. We ran a thorough literature search of PubMed, Web of Science, and Scopus, among other databases. We also thoroughly searched the literature listed in the papers. We searched all antibiotic resistance mechanisms and genes of seven important antibiotics used to treat K. pneumoniae infections. Antibiotics such as β-lactams, aminoglycosides, and quinolones are used in the treatment of K. pneumoniae infection. With both chromosomal and plasmid-encoded ARGs, this pathogen has diverse resistance genes. Carbapenem resistance genes, enlarged-spectrum β-lactamase genes, and AmpC genes are the most often β-lactamase resistance genes. K. pneumoniae is a major contributor to antibiotic resistance worldwide. Understanding K. pneumoniae antibiotic resistance mechanisms and molecular characteristics will be important for the design of targeted prevention and novel control strategies against this pathogen.
Bibliographic Details
Walter de Gruyter GmbH
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