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Biogenic amines and the psychopharmacology of aggression

Expert Opinion on Therapeutic Patents, ISSN: 1354-3776, Vol: 8, Issue: 4, Page: 349-359
1998
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Review Description

Neurobiological research has implicated a wide variety of neurochemical agents in the modulation of aggressive behaviour patterns. The biogenic amines serotonin, noradrenaline and dopamine have been the focus of much of this research. Recent advances in neuroscience have facilitated understanding of biogenic amine neurotransmission in the regulation of aggressive agonistic behaviour patterns in animal and primate models, as well as human populations suffering from neuropsychiatric illness. This article reviews recent developments in the field, drawing on both the primary and recent patent literature. A rationale for considering pharmacological intervention when aggression occurs as symptom of neuropsychiatric illness is discussed based on new developments in biogenic amine receptor physiology.

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