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Frequency and characterization of gastro-entero-pancreatic neuroendocrine tumor patients with high-grade of uptake at somatostatin receptor scintigraphy

Endocrine-Related Cancer, ISSN: 1351-0088, Vol: 20, Issue: 2, Page: 229-239
2013
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Article Description

Recent studies suggest that the somatostatin receptor scintigraphy (SRS) grade of uptake is a predictor of response to peptide receptor radionuclide therapy (PRRT). To identify and characterize patients with well-differentiated (WD) neuroendocrine neoplasm (NEN) displaying a high-grade uptake at SRS. Patients with WD-NEN, whose SRS films were available for review, were retrospectively included. SRS was reviewed by three independent readers and classified into four subgroups based on a modified Krenning's scale (mKS): no uptake (group-0), homogeneous grade 1-2 uptake (group-1), homogeneous grade 3-4 (group-2), and heterogeneous grade 1-4 (group-3). A simplified scale (sS) of SRS was also used to look for characteristics of patients with high-grade uptake. One hundred and six WD-NEN patients were enrolled. Group-0, group-1, group-2, and group-3 were found in 17, 8, 33, and 42% of cases respectively. High-grade uptake at sS (75% of cases) was correlated with older age, functioning NEN, high chromogranin-A level, and grade 1 (G1) NEN based on mitotic count. Based on the mKS or sS scales, no difference on survival was found. Thirty-three to seventy-five percent of metastatic NEN patients can be considered candidates for PRRT based on homogeneous or heterogeneous high-grade uptake. Functioning G1 NEN patients could be the best candidates for PRRT. Randomized trials are expected to confirm this result. © 2013 Society for Endocrinology.

Bibliographic Details

Chougnet, Cecile N; Leboulleux, Sophie; Caramella, Caroline; Lumbroso, Jean; Borget, Isabelle; Déandreis, Désirée; Duvillard, Pierre; Elias, Dominique; de Baere, Thierry; Vélayoudom-Céphise, Fritz-Line; Guigay, Joël; Ducreux, Michel; Schlumberger, Martin; Baudin, Eric

BioScientifica

Medicine; Biochemistry, Genetics and Molecular Biology

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