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Mutation accumulation, soft selection and the middle-class neighborhood

Genetics, ISSN: 0016-6731, Vol: 182, Issue: 4, Page: 1387-1389
2009
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Article Description

The "middle-class neighborhood" is a breeding design intended to allow new mutations to accumulate by lessening the effects of purifying selection through the elimination of among-line fitness variation. We show that this design effectively applies soft selection to the experimental population, potentially causing biased estimates of mutational effects if social effects contribute to fitness. Copyright © 2009 by the Genetics Society of America.

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