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Maternal phenylketonuria

Pediatrics, ISSN: 0031-4005, Vol: 107, Issue: 2, Page: 427-428
2001
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Article Description

Elevated maternal phenylalanine levels during pregnancy are teratogenic and may result in growth retardation, significant psychomotor handicaps, and birth defects in the offspring of unmonitored and untreated pregnancies. Women of childbearing age with all forms of phenylketonuria, including mild variants such as hyperphenylalaninemia, should receive counseling concerning their risks for adverse fetal effects optimally before conceiving. The best outcomes occur when strict control of maternal phenylalanine levels is achieved before conception and continued throughout the pregnancy.

Bibliographic Details

Felix De La Cruz; John Williams; James W. Hanson; Cynthia A. Moore; Michele Lloyd-Puryear; H. Eugene Hoyme; Christopher Cunniff; Jaime L. Frias; Celia Kaye; John B. Moeschler; Susan R. Panny; Tracy L. Trotter; Rebecca S. Wappner; Lauri Hall

American Academy of Pediatrics (AAP)

Medicine

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