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Validated liquid chromatographic method for analysis of the isomers of latanoprost

Acta Chromatographica, ISSN: 2083-5736, Vol: 20, Issue: 2, Page: 157-164
2008
  • 9
    Citations
  • 0
    Usage
  • 15
    Captures
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Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    9
    • Citation Indexes
      9
  • Captures
    15

Article Description

Baseline separation of latanoprost and its isomers 15(S)-latanoprost (impurity I) and 5,6-trans-latanoprost (impurity II) has been achieved for the first time by HPLC on an NH column with heptane-2-propanol- acetonitrile 93:6:1 (v/v), with addition of a small amount of water, as mobile phase. Validation of the method is described. © 2008 Akadémiai Kiadó, Budapest.

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