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Assessment of the cost-effectiveness of a quadrivalent HPV vaccine in Norway using a dynamic transmission model

Expert Review of Pharmacoeconomics and Outcomes Research, ISSN: 1473-7167, Vol: 8, Issue: 5, Page: 491-500
2008
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Metric Options:   Counts1 Year3 Year

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Article Description

To assess the epidemiological and economic impact of alternative quadrivalent human papillomavirus (HPV) vaccine strategies in Norway, we adapted a previously published dynamic transmission model. Vaccination of girls and women aged 12-24 years reduced the incidence of HPV 6/11/16/ 18-related genital warts, cervical intraepithelial neoplasia and cervical cancer by 94, 92 and 92% by year 100, respectively. The cost-effectiveness ratio for this strategy when compared with vaccinating girls before the age of 12 years only was 63,294 Norwegian kroner (€8272) per QALY gained. Based on this model and assumptions, implementation of a quadrivalent HPV vaccine national program in Norway could reduce the incidence of cervical cancer, cervical intraepithelial neoplasia and genital warts at a cost-effectiveness ratio within the range accepted as cost effective. © 2008 Expert Reviews Ltd.

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