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Hepatitis B virus genotypes: natural history and implications for treatment.

Expert review of gastroenterology & hepatology, ISSN: 1747-4132, Vol: 1, Issue: 2, Page: 321-328
2007
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Metric Options:   Counts1 Year3 Year

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Review Description

There are eight different genotypes named A-H. Genotypes have distinct geographic distribution in different regions of the world. There exists a difference in the disease profile between different genotypes. Genotype A compared with D, and B compared with C have earlier hepatitis B e-antigen seroconversion and less severe liver disease. However, genotypes are closely linked with core promoter and precore mutations. This may have a confounding effect on the association of genotypes with disease progression. Patients with genotype A compared with D and B compared with C have a better treatment response to IFN-alpha. However, there are no differences in the treatment response and rate of emergence of drug-resistant hepatitis B virus between different genotypes to nucleoside/nucleotide analog therapy.

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