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Current findings of fMRI in panic disorder: Contributions for the fear neurocircuitry and CBT effects

Expert Review of Neurotherapeutics, ISSN: 1473-7175, Vol: 10, Issue: 2, Page: 291-303
2010
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Review Description

Thanks to brain imaging great advances have been made concerning the comprehension of neural substrates related to panic disorder (PD). This article aims to: review the recent functional MRI (fMRI) studies concerning PD; correlate the PD fMRI neurobiological findings with the fear neurocircuitry hypothesis; discuss the fear neurocircuitry hypothesis and link it to cognitive - behavior therapy findings; and comment on fMRI study limitations and suggest methodological changes for future research. As a whole, there is increasing evidence that brain structures such as the prefrontal cortex, the anterior cingulate cortex and limbic areas (hippocampus and amygdala) might play a major role in the panic response. © 2010 Expert Reviews Ltd.

Bibliographic Details

de Carvalho, Marcele Regine; Dias, Gisele Pereira; Cosci, Fiammetta; de-Melo-Neto, Valfrido Leão; Bevilaqua, Mário Cesar do Nascimento; Gardino, Patricia Franca; Nardi, Antonio Egidio

Informa UK Limited

Neuroscience; Medicine

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