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Autoimmunity in chronic obstructive pulmonary disease: Clinical and experimental evidence

Expert Review of Clinical Immunology, ISSN: 1744-666X, Vol: 8, Issue: 3, Page: 285-292
2012
  • 77
    Citations
  • 0
    Usage
  • 62
    Captures
  • 1
    Mentions
  • 18
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    77
  • Captures
    62
  • Mentions
    1
    • News Mentions
      1
      • News
        1
  • Social Media
    18
    • Shares, Likes & Comments
      18
      • Facebook
        18

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Review Description

Over the past few decades, neutrophils and macrophages had co-occupied center stage as the critical innate immune cells underlying the pathobiology of cigarette smoke-induced chronic obstructive pulmonary disease and lung parenchymal destruction (i.e., emphysema). While chronic exposure to smoke facilitates the recruitment of innate immune cells into the lung, a clear role for adaptive immunity in emphysema has emerged. Evidence from human studies specifically point to a role for recruitment and activation of pathogenic lymphocytes and lung antigen-presenting cells in emphysema; similarly, animal models have confirmed a significant role for autoimumnity in progressive smoke-induced emphysema. Increased numbers of activated antigen-presenting cells, Th1 and Th17 cells, have been associated with smoke-induced lung inflammation and production of the canonical cytokines of these cells, IFN-γ and IL-17, correlates with disease severity. These exciting new breakthroughs could open new avenues for developing effective new therapies for smoke-induced emphysema. © 2012 Expert Reviews Ltd.

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