HLA-G molecules in pregnancy and their possiblei'role in assisted reproductive technology
Expert Review of Obstetrics and Gynecology, ISSN: 1747-4108, Vol: 4, Issue: 4, Page: 455-470
2009
- 3Citations
- 9Captures
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Review Description
Pregnancy is commonly considered a semi-allograft, as half of the fetal genome derives from the father. However, in normal pregnancy, several tolerance mechanisms have been demonstrated to counteract the maternal immune response. Among these, the expression of HLA-G by invasive cytotrophoblasts has shown to play a role in creating a tolerogenic condition at the feto-maternal interface. The possible role of HLA-G molecules in pregnancy and as a marker for oocyte/embryo selection in assisted reproduction technology is reviewed in this article, and the contrasting results present in the literature is compared. © 2009 Expert Reviews Ltd.
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