New Antithrombotic Aryl-sulfonylthiosemicarbazide Derivatives Synthesized from Natural Safrole
Journal of the Brazilian Chemical Society, ISSN: 0103-5053, Vol: 10, Issue: 5, Page: 421-428
1999
- 15Citations
- 6,990Usage
- 9Captures
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Article Description
As part of a research program aiming at the synthesis and pharmacological evaluation of novel lead-compounds exploring Brazilian abundant natural products, we describe herein the synthesis and the antithrombotic profile of new aryl-sulfonylsemicarbazides and aryl-sulfonylthiosemicarbazides (10a-d). The new derivatives, designed with basis on the molecular hybridization concept, were prepared in good yields from natural safrole (9), isolated from sassafras oil. The anti-aggregating activity of these new derivatives (10a-d) on platelet aggregation induced by ADP, collagen, arachidonic acid and U-46619, indicates an important antithrombotic profile for the 6-methyl-3,4-methylenedioxyphenyl-sulfonyl-N-phenylthiosemicarbazide derivative (10d). acting at the arachidonic acid cascade and representing a new lead-compound with antithrombotic activity.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0033266423&origin=inward; http://dx.doi.org/10.1590/s0103-50531999000500013; http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50531999000500013&lng=en&nrm=iso&tlng=en; http://www.scielo.br/pdf/jbchs/v10n5/a13v10n5.pdf; http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50531999000500013&lng=en&tlng=en; http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0103-50531999000500013&lng=en&tlng=en; http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50531999000500013; http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0103-50531999000500013; https://dx.doi.org/10.1590/s0103-50531999000500013; https://www.scielo.br/j/jbchs/a/W9V4zs9Y7CPBS5brMzZHNxz/?lang=en
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