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New Antithrombotic Aryl-sulfonylthiosemicarbazide Derivatives Synthesized from Natural Safrole

Journal of the Brazilian Chemical Society, ISSN: 0103-5053, Vol: 10, Issue: 5, Page: 421-428
1999
  • 15
    Citations
  • 6,990
    Usage
  • 9
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    15
    • Citation Indexes
      15
  • Usage
    6,990
  • Captures
    9

Article Description

As part of a research program aiming at the synthesis and pharmacological evaluation of novel lead-compounds exploring Brazilian abundant natural products, we describe herein the synthesis and the antithrombotic profile of new aryl-sulfonylsemicarbazides and aryl-sulfonylthiosemicarbazides (10a-d). The new derivatives, designed with basis on the molecular hybridization concept, were prepared in good yields from natural safrole (9), isolated from sassafras oil. The anti-aggregating activity of these new derivatives (10a-d) on platelet aggregation induced by ADP, collagen, arachidonic acid and U-46619, indicates an important antithrombotic profile for the 6-methyl-3,4-methylenedioxyphenyl-sulfonyl-N-phenylthiosemicarbazide derivative (10d). acting at the arachidonic acid cascade and representing a new lead-compound with antithrombotic activity.

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