Tanshinone IIA ameliorates myocardial ischemia/reperfusion injury in rats by regulation of NLRP3 inflammasome activation and Th17 cells differentiation
Acta Cirurgica Brasileira, ISSN: 1678-2674, Vol: 37, Issue: 7, Page: e370701
2022
- 11Citations
- 6Captures
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Metrics Details
- Citations11
- Citation Indexes11
- 11
- Captures6
- Readers6
Article Description
Purpose: Tanshinone IIA is a well-known lipophilic active constituent refined from traditional Chinese medicines, danshen. It has been previously demonstrated to possess various biological properties, including anti-inflammatory, antioxidant, promoting angiogenesis effect and so on. However, the mechanism of tanshinone IIA on myocardial ischemia-reperfusion injury (MI/RI) remains unclear. In this study, we investigated the effect of tanshinone IIA on MI/RI. Methods: MI/RI rat models were set up. Echocardiographic evaluation and hematoxylin and eosin staining were performed to analyze the cardiac function and morphology of MI/RI. Western blot was conducted for the detection of protein expression of pyrin domain containing 3 (NLRP3) and caspase-1 in heart tissues. Flow cytometry and real-time polymerase chain reaction were used for the detection of proinflammatory cytokines and Th17 cells differentiation. Results: We found that tanshinone IIA alleviated the myocardial damage of MI/RI, ameliorated the overall and local inflammatory reaction, and produced a cardioprotective effect by inhibiting of NLRP3 inflammasome activation and Th17/Treg cells differentiation. Conclusion: Our results highlighted the cardio-protective effect of tanshinone IIA on MI/RI and uncovered its underlying mechanism related to the NLRP3 inflammasome inhibition and the modulation of Th17/Treg cells differentiation.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85140832637&origin=inward; http://dx.doi.org/10.1590/acb370701; http://www.ncbi.nlm.nih.gov/pubmed/36327403; http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502022000700202&tlng=en; http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502022000700202&lng=en&tlng=en; http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0102-86502022000700202&lng=en&tlng=en; http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502022000700202; http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0102-86502022000700202; https://dx.doi.org/10.1590/acb370701; https://www.scielo.br/j/acb/a/z3JZqdPRPTvBwS85fzNtgNQ/?lang=en
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