Perfil hormonal e metabólico em pacientes hirsutas com a síndrome dos ovários policísticos
Arquivos Brasileiros de Endocrinologia & Metabologia, ISSN: 1677-9487, Vol: 45, Issue: 4, Page: 352-360
2001
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Article Description
A síndrome dos ovários policísticos (PCOS) tem sido associada à resistência insulínica/hiperinsulinemia compensatória e a uma maior prevalência de intolerância aos carboidratos (ICH) e diabetes mellitus tipo 2 (DM2). Há controvérsia na literatura sobre se a hiperinsulinemia, presente nas pacientes com PCOS, é independente ou não da obesidade. No presente estudo, avaliaram-se as características hormonais e o perfil metabólico glico-insulínico e lipídico em mulheres hirsutas com o diagnóstico de PCOS em comparação com pacientes com hirsutismo idiopático (HI), estratificadas de acordo com o índice de massa corporal (IMC <= ou > 25kg/m²). Foram dosados androgênios, SHBG, gonadotrofinas, além de glicose, lipídeos e lipoproteínas, insulina e pró-insulina. Foi também realizado o teste de tolerância oral à glicose (75g) para avaliação da curva de glicose e insulina. Concluímos que as pacientes com PCOS e IMC > 25kg/m² apresentam maior prevalência de obesidade abdominal, de hiperinsulinemia, hipertrigliceridemia e curvas glicêmicas alteradas em relação às pacientes PCOS e IMC <= 25kg/m² e ao grupo controle estudado de pacientes com hirsutismo idiopático
Bibliographic Details
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302001000400007&lng=pt&tlng=pt; http://www.scielo.br/pdf/abem/v45n4/a07v45n4.pdf; http://dx.doi.org/10.1590/s0004-27302001000400007; http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302001000400007&lng=en&tlng=en; http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0004-27302001000400007&lng=en&tlng=en; http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302001000400007; http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0004-27302001000400007; https://dx.doi.org/10.1590/s0004-27302001000400007; https://www.scielo.br/j/abem/a/xdFfRhpyF6LPbnXTzXdHnJg/?lang=pt
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