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Oncogenic osteomalacia: Localization of underlying peripheral tumor with Tc-sestamibi scintigraphy

Arquivos Brasileiros de Endocrinologia e Metabologia, ISSN: 0004-2730, Vol: 52, Issue: 9, Page: 1505-1509
2008
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Article Description

Oncogenic osteomalacia is a paraneoplastic syndrome usually induced by bone or soft tissue tumors. It is presented by the development of pain and fractures with hypophosphatemia, hyperphosphaturia, and inappropriate normal/low plasma 1,25(OH) D concentration. After the removal of the tumor the complete resolution of all biochemical and clinical abnormalities is the main characteristic. A case of a 44-year-old female with difficulty in walking due to leg pain and generalized muscle weakness and hypophosphatemia, with relative hyperphosphaturia, is described. A whole-body Tc- sestamibi scintigraphy showed accumulation in the left thigh region, and a small tumor was detected by ultrasound examination. By removal of the tumor, a lipoma, the symptoms improved significantly after a month, with complete recovery by the fourth month. In this case, Tc-sestamibi scintigraphy was useful in identifying the location of the tumor, which caused oncogenic osteomalacia. Copyright© ABE&M.

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