Influence of local or systemic corticosteroids on skin wound healing resistance
Acta Cirurgica Brasileira, ISSN: 1678-2674, Vol: 27, Issue: 4, Page: 296-299
2012
- 11Citations
- 13,463Usage
- 20Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations11
- Citation Indexes11
- 11
- CrossRef5
- Scielo1
- Usage13,463
- Full Text Views12,649
- 12,649
- Abstract Views814
- 814
- Captures20
- Readers20
- 20
Article Description
PURPOSE: To compare the resistance of skin wound healing of mice submitted to local or systemic hydrocortisone administration, in different postoperative periods. METHODS: An incision and suture was performed on the thoracic skin of 130 male mice: Group 1 (n = 10) resistance of the integer skin; Group 2 (n = 30) submitted only to skin incision and suture; Group 3 (n = 30) skin incision and suture followed by administration of saline fluid; Group 4 (n = 30) skin incision and suture followed by administration of local hydrocortisone; Group 5 (n = 30) skin incision and suture followed by administration of systemic hydrocortisone. The resistance of the wound healing and the weight of the animals were studied on the seventh, 14 and 21 postoperative days. Histological examination was also performed. RESULTS: The mice that received corticoid (groups 4 and 5) presented significant decreasing on their weight (p = 0.02). The Groups 3, 4 and 5 showed lower scar resistance than Group 2 on the seventh postoperative day (p < 0.05). On the 14 and 21 days, there was no difference on the skin would healing resistance (p > 0.05). CONCLUSION: Administration of hydrocortisone in mice is responsible for weight decreasing and reduction of the skin wound healing resistance during the first postoperative week.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84860717396&origin=inward; http://dx.doi.org/10.1590/s0102-86502012000400003; http://www.ncbi.nlm.nih.gov/pubmed/22534803; http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012000400003&lng=en&tlng=en; http://www.scielo.br/pdf/acb/v27n4/v27n4a03.pdf; http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0102-86502012000400003&lng=en&tlng=en; http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012000400003; http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0102-86502012000400003; https://dx.doi.org/10.1590/s0102-86502012000400003; https://www.scielo.br/j/acb/a/Xj3Y3SNPGFMVgWkMvyMJDsn/?lang=en
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