The liver injury following ischemia and reperfusion is worse in experimental knockout heterozygote mouse model for expression of connexin 43
Acta Cirurgica Brasileira, ISSN: 1678-2674, Vol: 34, Issue: 10, Page: e201901003
2019
- 2Citations
- 918Usage
- 16Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations2
- Citation Indexes2
- CrossRef2
- Usage918
- Full Text Views781
- 781
- Abstract Views137
- 137
- Captures16
- Readers16
- 16
Article Description
Purpose: To evaluate that Connexin (Cx43) plays a role in lesions after hepatic ischemia/reperfusion (IR) injury. Methods: We use Cx43 deficient model (heterozygotes mice) and compared to a wild group. The groups underwent 1 hour ischemia and 24 hours reperfusion. The heterozygote genotype was confirmed by PCR. We analyzed the hepatic enzymes (AST, ALT, GGT) and histology. Results: The mice with Cx43 deficiency showed an ALT mean value of 4166 vs. 307 in the control group (p<0.001); AST mean value of 7231 vs. 471 in the control group (p<0.001); GGT mean value of 9.4 vs. 1.7 in the control group (p=0.001); histology showed necrosis and inflammation in the knockout group. Conclusions: This research demonstrated that the deficiency of Cx43 worses the prognosis for liver injury. The topic is a promising target for therapeutics advancements in liver diseases and procedures.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85076976883&origin=inward; http://dx.doi.org/10.1590/s0102-865020190100000003; http://www.ncbi.nlm.nih.gov/pubmed/31851211; http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502019001000212&tlng=en; http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502019001000212&lng=en&tlng=en; http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0102-86502019001000212&lng=en&tlng=en; http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502019001000212; http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0102-86502019001000212; https://dx.doi.org/10.1590/s0102-865020190100000003; https://www.scielo.br/j/acb/a/j6nN4zDtsWXZLf9N4bJtWbD/?lang=en
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